Targeting cardiac fibrosis in heart failure with preserved ejection fraction: mirage or miracle?

M Sweeney, B Corden, SA Cook - EMBO molecular medicine, 2020 - embopress.org
Cardiac fibrosis is central to the pathology of heart failure, particularly heart failure with
preserved ejection fraction (HF p EF). Irrespective of the underlying profibrotic condition (eg …

Stroke–heart syndrome: recent advances and challenges

JF Scheitz, LA Sposato, J Schulz‐Menger… - Journal of the …, 2022 - Am Heart Assoc
After ischemic stroke, there is a significant burden of cardiovascular complications, both in
the acute and chronic phase. Severe adverse cardiac events occur in 10% to 20% of …

Valvular heart disease: shifting the focus to the myocardium

N Ajmone Marsan, V Delgado, DJ Shah… - European heart …, 2023 - academic.oup.com
Adverse cardiac remodelling is the main determinant of patient prognosis in degenerative
valvular heart disease (VHD). However, to give an indication for valvular intervention …

[HTML][HTML] Extracellular volume quantification with cardiac late enhancement scanning using dual-source photon-counting detector CT

V Mergen, T Sartoretti, E Klotz, B Schmidt… - Investigative …, 2022 - journals.lww.com
Objectives The aim of this study was to evaluate the feasibility and accuracy of cardiac late
enhancement (LE) scanning for extracellular volume (ECV) quantification with dual-source …

Cardiac virtual noncontrast images for calcium quantification with photon-counting detector CT

V Mergen, S Ghouse, T Sartoretti, R Manka… - Radiology …, 2023 - pubs.rsna.org
Purpose To assess the accuracy of aortic valve calcium (AVC), mitral annular calcium
(MAC), and coronary artery calcium (CAC) quantification and risk stratification using virtual …

Markers of myocardial damage predict mortality in patients with aortic stenosis

S Kwak, RJ Everett, TA Treibel, S Yang… - Journal of the American …, 2021 - jacc.org
Background Cardiovascular magnetic resonance (CMR) is increasingly used for risk
stratification in aortic stenosis (AS). However, the relative prognostic power of CMR markers …

[HTML][HTML] Left ventricular myocardial work in patients with severe aortic stenosis

F Fortuni, SC Butcher, F van der Kley… - Journal of the American …, 2021 - Elsevier
Background Left ventricular myocardial work (LVMW) is a novel method to assess left
ventricular (LV) function using pressure-strain loops that takes into consideration LV …

Markers of focal and diffuse nonischemic myocardial fibrosis are associated with adverse cardiac remodeling and prognosis in patients with hypertension: the …

NR Iyer, TT Le, MSL Kui, HC Tang, CT Chin… - …, 2022 - Am Heart Assoc
Background: The prognostic significance of focal and diffuse myocardial fibrosis in patients
with cardiovascular risk factors is unclear. Methods: REMODEL (Response of the …

Multimodality imaging assessment of myocardial fibrosis

S Gupta, Y Ge, A Singh, C Gräni, RY Kwong - Cardiovascular Imaging, 2021 - jacc.org
Myocardial fibrosis, seen in ischemic and nonischemic cardiomyopathies, is associated with
adverse cardiac outcomes. Noninvasive imaging plays a key role in early identification and …

Characterizing the heart and the myocardium with photon-counting CT

E Zsarnóczay, A Varga-Szemes, T Emrich… - Investigative …, 2023 - journals.lww.com
Noninvasive cardiac imaging has rapidly evolved during the last decade owing to
improvements in computed tomography (CT)–based technologies, among which we …