Programmed death receptor ligand 1 (PD-L1, also called B7-H1) is a recently described B7
family member. In contrast to B7-1 and B7-2, PD-L1 does not interact with either CD28 or …

Over expression of B7-H1 (also named PDL-1 or CD 274) molecule in cancer has been
linked to worse prognosis and resistance to anti-cancer therapies in several malignancies …

T cell therapies require the removal and culture of T cells ex vivo to expand several
thousand‐fold. However, these cells often lose the phenotype and cytotoxic functionality for …

Human tumors frequently escape immune destruction, despite the presence of cyototoxic T
cells (CTL) recognizing tumor‐associated antigens (TAA). We have previously shown that …

Purpose The adoptive transfer of in vitro generated tumor antigen-specific cytotoxic T
lymphocytes (CTL) provides a promising approach to the immunotherapy of cancer. A phase …

Adoptive immunotherapy holds promise as a treatment for cancer and infectious diseases,
but its development has been impeded by the lack of reproducible methods for generating …

Antigen-specific priming of human, naive T cells has been difficult to assess. Owing to the
low initial frequency in the naive cell pool of specific T cell precursors, such an analysis has …

Background: To identify immunosuppressive elements present in ovarian cancer associated
ascites. Patients and Methods: Ascites and plasma were obtained from ovarian, primary …

Adoptive immunotherapy (AIT) can mediate durable regression of cancer, but widespread
adoption of AIT is limited by the cost and complexity of generating tumor-specific T cells …

Innovations in gene discovery and the analysis of gene expression are facilitating the
identification of a growing number of antigens that could potentially be targeted for …