The myelodysplastic syndromes (MDSs) are common, acquired, clinically challenging
hematologic conditions that are characterized by bone marrow failure and a risk of …

Fanconi anaemia (FA) is a rare, autosomal recessive, genetically complex, DNA repair
deficiency syndrome in man. Patients with FA exhibit a heterogeneous spectrum of clinical …

In all, 447 children with acute myeloid leukaemia (AML) have been treated on three
consecutive NOPHO studies from July 1984 to December 2001. NOPHO-AML 84 was of …

Abstract Monosomy 7 (− 7) and deletion 7q\del (7q) are rare in childhood acute myeloid
leukemia (AML). We retrospectively collected data on 258 children with AML or refractory …

To identify cytogenetic risk factors predicting outcome in children with advanced
myelodysplastic syndrome, overall survival of 192 children prospectively enrolled in …

Myelodysplastic syndromes (MDS) and the mixed myelodysplastic/myeloproliferative
disorder juvenile myelomonocytic leukaemia (JMML) are rare haematopoietic stem cell …

Aberrant DNA methylation contributes to the malignant phenotype in virtually all types of
cancer, including myeloid leukemia. We hypothesized that CpG island hypermethylation …

Since 2002, date of publication of the previous Italian Society of Haematology (SIE) practice
guidelines for management of myelodysplastic syndromes (MDS), novel disease-modifying …

Juvenile myelomonocytic leukemia (JMML) is a rare pediatric myeloid neoplasm
characterized by excessive proliferation of myelomonocytic cells. When we investigated the …

Myelodysplastic syndromes (MDS) belong to the most frequent bone marrow diseases with
a crude incidence of about 4 in 100,000 per year. The diagnosis of MDS still is mainly based …