Cyclin dependent kinases (CDKs) are serine/threonine kinases that are proposed as
promising candidate targets for cancer treatment. These proteins complexed with cyclins …

Altered gene expression is a characteristic feature of many disease states such as
tumorigenesis, and in most cancers, it facilitates cancer cell survival and adaptation …

Discoveries made over the past 20 years highlight the importance of mRNA decay as a
means of modulating gene expression and thereby protein production. Up until recently …

Posttranscriptional gene regulation relies on hundreds of RNA binding proteins (RBPs) but
the function of most RBPs is unknown. The human RBP HuR/ELAVL1 is a conserved mRNA …

The RNA-binding proteins (RBPs) are critical trans factors that associate with specific cis
elements present in mRNAs whose stability and translation are subject to regulation. The …

The RNA‐binding protein HuR (human antigen R) associates with numerous transcripts,
coding and noncoding, and controls their splicing, localization, stability, and translation …

RNA-binding proteins (RBPs) and microRNAs (miRNAs) are potent post-transcriptional
regulators of gene expression. Here, we show that the RBP HuR reduced c-Myc expression …

The cytoplasmic events that control mammalian gene expression, primarily mRNA stability
and translation, potently influence the cellular response to internal and external signals. The …

The human embryonic lethal abnormal vision-like protein, HuR, is a member of the Hu family
of RNA-binding proteins. Over the past decade, this ubiquitously expressed protein has …

Cancer‐related gene expression programs are strongly influenced by posttranscriptional
mechanisms. The RNA‐binding protein HuR is highly abundant in many cancers. Numerous …