In patients with Parkinson's disease, heterogeneous cholinergic system changes can occur
in different brain regions. These changes correlate with a range of clinical features, both …

Here we argue functional neuroanatomy for posture-gait control. Multi-sensory information
such as somatosensory, visual and vestibular sensation act on various areas of the brain so …

Deep brain stimulation (DBS) is widely used for the treatment of movement disorders
including Parkinson's disease, essential tremor, and dystonia and, to a lesser extent, certain …

Background Freezing of gait (FOG) is a common, disabling symptom of Parkinson's disease
(PD), but the mechanisms and treatments of FOG remain great challenges for clinicians and …

Deep brain stimulation (DBS) has become the treatment of choice for advanced stages of
Parkinson's disease, medically intractable essential tremor, and complicated segmental and …

Neuromechanical principles define the properties and problems that shape neural solutions
for movement. Although the theoretical and experimental evidence is debated, we present …

Freezing of gait is a common and disabling symptom in patients with parkinsonism,
characterised by sudden and brief episodes of inability to produce effective forward …

Deep brain stimulation (DBS) is an established procedure for the symptomatic treatment of
Parkinson's disease. Several deep brain nuclei have been stimulated, producing a wide …

Axial motor signs—including gait impairment, postural instability and postural abnormalities—
are common and debilitating symptoms in patients with advanced Parkinson disease …

The current definition of major depressive disorder (MDD) emerged from efforts to create
reliable diagnostic criteria for clinical and research use. However, despite decades of …