Natural products and their structural analogues have historically made a major contribution
to pharmacotherapy, especially for cancer and infectious diseases. Nevertheless, natural …

Covering: 2006 to 2016 The computational mining of genomes has become an important
part in the discovery of novel natural products as drug leads. Thousands of bacterial …

Microorganisms produce a wealth of structurally diverse specialized metabolites with a
remarkable range of biological activities and a wide variety of applications in medicine and …

Although biosynthetic gene clusters (BGCs) have been discovered for hundreds of bacterial
metabolites, our knowledge of their diversity remains limited. Here, we used a novel …

Streptomycetes are the most abundant source of antibiotics. Typically, each species
produces several antibiotics, with the profile being species specific. Streptomyces coelicolor …

Natural product libraries contain specialized metabolites derived from plants, animals, and
microorganisms that play a pivotal role in drug discovery due to their immense structural …

A systematic analysis of all naturally-occurring glycosylated bacterial secondary metabolites
reported in the scientific literature up through early 2013 is presented. This comprehensive …

Recent developments in next-generation sequencing technologies have brought recognition
of microbial genomes as a rich resource for novel natural product discovery. However …

The vast majority of systemic bacterial infections are caused by facultative, often antibiotic-
resistant, pathogens colonizing human body surfaces. Nasal carriage of Staphylococcus …

Review covering up to mid-2021 The structure of polyketide and non-ribosomal peptide
natural products is strongly influenced by how they are released from their biosynthetic …