One hundred years ago, Ramón y Cajal, considered by many as the founder of modern
neuroscience, stated that neurons of the adult central nervous system (CNS) are incapable …

Neuronal microenvironment imbalance is associated with successive and irreversible
pathophysiological changes and insufficient functional restoration after peripheral nerve …

Mitochondrial-derived vesicles (MDVs) are implicated in diverse physiological processes—
for example, mitochondrial quality control—and are linked to various neurodegenerative …

Mitochondria sense and respond to many stressors and can support cell survival or death
through energy production and signalling pathways. Mitochondrial responses depend on …

Permanent disabilities following CNS injuries result from the failure of injured axons to
regenerate and rebuild functional connections with their original targets. By contrast, injury …

Synapses enable neurons to communicate with each other and are therefore a prerequisite
for normal brain function. Presynaptically, this communication requires energy and …

Neurons have more extended and complex shapes than other cells and consequently face a
greater challenge in distributing and maintaining mitochondria throughout their arbors …

Mitochondrial transport along microtubules is mediated by Miro1 and TRAK adaptors that
recruit kinesin-1 and dynein-dynactin. To understand how these opposing motors are …

In the current model of mitochondrial trafficking, Miro1 and Miro2 Rho‐GTP ases regulate
mitochondrial transport along microtubules by linking mitochondria to kinesin and dynein …

After an injury in the adult mammalian central nervous system (CNS), lesioned axons fail to
regenerate. This failure to regenerate contrasts with axons' remarkable potential to grow …