Importance Glaucoma is a worldwide leading cause of irreversible vision loss. Because it
may be asymptomatic until a relatively late stage, diagnosis is frequently delayed. A general …

Primary angle-closure glaucoma (PACG) is a common cause of blindness. Angle closure is
a fundamental pathologic process in PAGC. With the development of imaging devices for the …

The trabecular meshwork (TM) is located in the anterior segment of the eye and is
responsible for regulating the outflow of aqueous humor. Increased resistance to aqueous …

Osteoarthritis has a highly negative impact on quality of life because of the associated pain
and loss of joint function. Here we describe the largest meta-analysis so far of osteoarthritis …

Primary angle‐closure glaucoma is potentially a devastating disease, responsible for half of
glaucoma‐related blindness worldwide. Angle closure is characterized by appositional …

Thioredoxin reductases (TrxRs) belong to the pyridine nucleotide disulfide oxidoreductase
family enzymes that reduce thioredoxin (Trx). The couple TrxR and Trx is one of the major …

Genetic and genomic studies, including genome-wide association studies (GWAS) have
accelerated the discovery of genes contributing to glaucoma, the leading cause of …

Glaucoma, the world's leading cause of irreversible blindness, is a complex disease, with
differential presentation as well as ethnic and geographic disparities. The multifactorial …

Brain-derived neurotrophic factor (BDNF) has a unique role in the neuronal development,
differentiation, and survival in the developing and adult nervous system. A common single …

Age-related macular degeneration (AMD) is a major cause of blindness, but presents
differently in Europeans and Asians. Here, we perform a genome-wide and exome-wide …