[HTML][HTML] Protein structure-based in-silico approaches to drug discovery: Guide to COVID-19 therapeutics
With more than 5 million fatalities and close to 300 million reported cases, COVID-19 is the
first documented pandemic due to a coronavirus that continues to be a major health …
first documented pandemic due to a coronavirus that continues to be a major health …
Sub‐lineages of the SARS‐CoV‐2 Omicron variants: Characteristics and prevention
A Xu, B Hong, F Lou, S Wang, W Li, A Shafqat… - MedComm, 2022 - Wiley Online Library
Since the start of the coronavirus disease 2019 (COVID‐19) pandemic, new variants of
severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) have emerged …
severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) have emerged …
[HTML][HTML] SARS-CoV-2 variants with NSP12 P323L/G671S mutations display enhanced virus replication in ferret upper airways and higher transmissibility
SM Kim, EH Kim, MAB Casel, YI Kim, R Sun, MJ Kwak… - Cell reports, 2023 - cell.com
With the emergence of multiple predominant SARS-CoV-2 variants, it becomes important to
have a comprehensive assessment of their viral fitness and transmissibility. Here, we …
have a comprehensive assessment of their viral fitness and transmissibility. Here, we …
Discovery of GS-5245 (obeldesivir), an oral prodrug of nucleoside GS-441524 that exhibits antiviral efficacy in SARS-CoV-2-infected African green monkeys
Remdesivir 1 is an phosphoramidate prodrug that releases the monophosphate of
nucleoside GS-441524 (2) into lung cells, thereby forming the bioactive triphosphate 2-NTP …
nucleoside GS-441524 (2) into lung cells, thereby forming the bioactive triphosphate 2-NTP …
Determinants and mechanisms of the low Fusogenicity and high dependence on endosomal entry of omicron subvariants
The rapid spread and strong immune evasion of the SARS-CoV-2 Omicron subvariants has
raised serious concerns for the global COVID-19 pandemic. These new variants exhibit …
raised serious concerns for the global COVID-19 pandemic. These new variants exhibit …
[HTML][HTML] 1, 2, 3-triazole-benzofused molecular conjugates as potential antiviral agents against SARS-CoV-2 virus variants
SARS-CoV-2 and its variants, especially the Omicron variant, remain a great threat to human
health. The need to discover potent compounds that may control the SARS-CoV-2 virus …
health. The need to discover potent compounds that may control the SARS-CoV-2 virus …
Evaluation of antiviral drugs against newly emerged SARS-CoV-2 Omicron subvariants
J Cho, Y Shin, JS Yang, JW Kim, KC Kim, JY Lee - Antiviral research, 2023 - Elsevier
Ongoing emergence of SARS-CoV-2 Omicron subvariants and their rapid worldwide spread
pose a threat to public health. From November 2022 to February 2023, newly emerged …
pose a threat to public health. From November 2022 to February 2023, newly emerged …
Viral resistance analyses from the remdesivir Phase 3 Adaptive COVID-19 Treatment Trial-1 (ACTT-1)
C Hedskog, L Rodriguez… - The Journal of …, 2023 - academic.oup.com
Background Remdesivir is approved for treatment of coronavirus disease 2019 (COVID-19)
in nonhospitalized and hospitalized adult and pediatric patients. Here we present severe …
in nonhospitalized and hospitalized adult and pediatric patients. Here we present severe …
[HTML][HTML] Current understanding of nucleoside analogs inhibiting the SARS-CoV-2 RNA-dependent RNA polymerase
T Xu, L Zhang - Computational and Structural Biotechnology Journal, 2023 - Elsevier
Since the outbreak of the COVID-19 pandemic, severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) RNA-dependent RNA polymerase (RdRp) has become a main …
coronavirus 2 (SARS-CoV-2) RNA-dependent RNA polymerase (RdRp) has become a main …
In Vitro Selection of Remdesivir-Resistant SARS-CoV-2 Demonstrates High Barrier to Resistance
L Checkmahomed, J Carbonneau… - Antimicrobial Agents …, 2022 - Am Soc Microbiol
In vitro selection of remdesivir-resistant severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) revealed the emergence of a V166L substitution, located outside of the …
(SARS-CoV-2) revealed the emergence of a V166L substitution, located outside of the …