The nervous system development regulator neuropilin-1 as a potential prognostic marker and therapeutic target in brain cancer

EM Rodrigues, AF Giovanini, CAPM Ribas, O Malafaia… - Cancers, 2023 - mdpi.com
Simple Summary Dysregulation of molecular mechanisms that regulate nervous system
development may be at the origin of brain tumors. We reviewed the role of neuropilin-1 …

Neuropilin-1 as a potential biomarker of prognosis and invasive-related parameters in liver and colorectal cancer: A systematic review and meta-analysis of human …

P Fernández-Palanca, T Payo-Serafín, F Fondevila… - Cancers, 2022 - mdpi.com
Simple Summary Neuropilin-1 (NRP1) is a transmembrane protein which has had recently
increased interest from cancer researchers. Liver cancer and colorectal cancer (CRC) are …

Plexin-A2 enables the proliferation and the development of tumors from glioblastoma derived cells

S Toledano, AD Sabag, N Ilan, T Liburkin-Dan… - Cell Death & …, 2023 - nature.com
The semaphorin guidance factors receptor plexin-A2 transduces sema6A and sema6B
signals and may mediate, along with plexin-A4, the anti-angiogenic effects of sema6A …

Role of semaphorin 3A in kidney development and diseases

Y Sang, K Tsuji, H Nakanoh, K Fukushima, S Kitamura… - Diagnostics, 2023 - mdpi.com
Kidney diseases are worldwide public health problems affecting millions of people.
However, there are still limited therapeutic options against kidney diseases. Semaphorin 3A …

Glomerular endothelial cells are the coordinator in the development of diabetic nephropathy

T Li, K Shen, J Li, SWS Leung, T Zhu, Y Shi - Frontiers in Medicine, 2021 - frontiersin.org
The prevalence of diabetes is consistently rising worldwide. Diabetic nephropathy is a
leading cause of chronic renal failure. The present study aimed to explore the crosstalk …

Single-cell RNA-seq reveals the communications between extracellular matrix-related components and Schwann cells contributing to the earlobe keloid formation

T Gong, Y Wang, S Dong, X Ma, D Du, C Zou… - Frontiers in …, 2022 - frontiersin.org
Keloid is a major type of skin fibrotic disease, with one prominent feature of extensive
accumulation of extracellular matrix (ECM) components, and another feature of pain/itching …

Promotion of gastric tumor initiating cells in a 3D collagen gel culture model via YBX1/SPP1/NF-κB signaling

S Deng, L Li, S Xu, X Wang, T Han - Cancer Cell International, 2021 - Springer
Background The high potential for tumor recurrence and chemoresistance is a major
challenge of clinical gastric cancer treatment. Increasing evidence suggests that the …

mRNA markers for survival prediction in glioblastoma multiforme patients: a systematic review with bioinformatic analyses

P Azimi, T Yazdanian, A Ahmadiani - BMC cancer, 2024 - Springer
Background Glioblastoma multiforme (GBM) is a type of fast-growing brain glioma
associated with a very poor prognosis. This study aims to identify key genes whose …

NK/DC crosstalk-modulating antitumor activity via Sema3E/PlexinD1 axis for enhanced cancer immunotherapy

A Ali, A Alamri, A Hajar - Immunologic Research, 2024 - Springer
The complex relationship between natural killer (NK) cells and dendritic cells (DCs) within
the tumor microenvironment significantly impacts the success of cancer immunotherapy …

Transcriptomic profiling revealed plexin A2 downregulation with migration and invasion alteration in dacarbazine-treated primary melanoma cells

A Tyumentseva, A Averchuk, N Palkina… - Frontiers in …, 2021 - frontiersin.org
Melanoma is highly heterogeneous type of malignant neoplasm that is responsible for the
majority of deaths among other types of skin cancer. In the present study, we screened a list …