Spermatogonial stem cells (SSCs) are the only adult stem cells capable of passing genes
onto the next generation. SSCs also have the potential to provide important knowledge …

BACKGROUND Fertility in adult life may be severely impaired by gonadotoxic therapies. For
young boys who do not yet produce spermatozoa, cryopreservation of immature testicular …

Purpose To develop guidance to practicing oncologists about available fertility preservation
methods and related issues in people treated for cancer. Methods An expert panel and a …

BACKGROUND Banking of testicular tissue from pre-pubertal boys before gonadotoxic
treatment is a crucial step in fertility preservation. We wanted to find optimal methods for …

Abstract Three-dimensional (3D) organoids can serve as an in vitro platform to study cell–
cell interactions, tissue development, and toxicology. Development of organoids with tissue …

Infertility is a prevalent condition that has insidious impacts on the infertile individuals, their
families, and society, which extend far beyond the inability to have a biological child …

BACKGROUND Childhood cancer incidence and survivorship are both on the rise.
However, many lifesaving treatments threaten the prepubertal testis. Cryopreservation of …

BACKGROUND Preservation of the male germ line in prepubertal boys undergoing
gonadotoxic treatment is a crucial consideration in terms of their future quality of life. As …

Medical treatments for cancers or other conditions can lead to permanent infertility. Infertility
is an insidious disease that impacts not only the ability to have a biological child but also the …

Human reproductive organs are of vital importance to the life of an individual and the
reproduction of human populations. So far, traditional methods have a limited effect in …