Photoreceptor cells and RPE contribute to the development of diabetic retinopathy
D Tonade, TS Kern - Progress in retinal and eye research, 2021 - Elsevier
Diabetic retinopathy (DR) is a leading cause of blindness. It has long been regarded as
vascular disease, but work in the past years has shown abnormalities also in the neural …
vascular disease, but work in the past years has shown abnormalities also in the neural …
Risk factors and biomarkers of age-related macular degeneration
NG Lambert, H ElShelmani, MK Singh… - Progress in retinal and …, 2016 - Elsevier
A biomarker can be a substance or structure measured in body parts, fluids or products that
can affect or predict disease incidence. As age-related macular degeneration (AMD) is the …
can affect or predict disease incidence. As age-related macular degeneration (AMD) is the …
Mapping the proteo-genomic convergence of human diseases
INTRODUCTION Proteins are essential functional units of the human body and represent
the largest class of drug targets. RATIONALE Broad-capture proteomics has the potential to …
the largest class of drug targets. RATIONALE Broad-capture proteomics has the potential to …
Reprogramming to recover youthful epigenetic information and restore vision
Ageing is a degenerative process that leads to tissue dysfunction and death. A proposed
cause of ageing is the accumulation of epigenetic noise that disrupts gene expression …
cause of ageing is the accumulation of epigenetic noise that disrupts gene expression …
Soft drusen in age-related macular degeneration: biology and targeting via the oil spill strategies
CA Curcio - Investigative ophthalmology & visual science, 2018 - iovs.arvojournals.org
AMD is a major cause of legal blindness in older adults approachable through
multidisciplinary research involving human tissues and patients. AMD is a vascular …
multidisciplinary research involving human tissues and patients. AMD is a vascular …
Measuring the contributions of basal laminar deposit and Bruch's membrane in age-related macular degeneration
AA Sura, L Chen, JD Messinger… - … & visual science, 2020 - iovs.arvojournals.org
Purpose: Basal laminar deposit (BLamD) is a consistent finding in age-related macular
degeneration (AMD). We quantified BLamD thickness, appearance, and topography in eyes …
degeneration (AMD). We quantified BLamD thickness, appearance, and topography in eyes …
Age-related macular degeneration: etiology, pathogenesis, and therapeutic strategies
J Ambati, BK Ambati, SH Yoo, S Ianchulev… - Survey of …, 2003 - Elsevier
Age-related macular degeneration is the principal cause of registered legal blindness
among those aged over 65 in the United States, western Europe, Australia, and Japan …
among those aged over 65 in the United States, western Europe, Australia, and Japan …
Role of epithelial-mesenchymal transition in retinal pigment epithelium dysfunction
Retinal pigment epithelial (RPE) cells maintain the health and functional integrity of both
photoreceptors and the choroidal vasculature. Loss of RPE differentiation has long been …
photoreceptors and the choroidal vasculature. Loss of RPE differentiation has long been …
Involvement of a gut–retina axis in protection against dietary glycemia-induced age-related macular degeneration
Age-related macular degeneration (AMD) is the major cause of blindness in developed
nations. AMD is characterized by retinal pigmented epithelial (RPE) cell dysfunction and …
nations. AMD is characterized by retinal pigmented epithelial (RPE) cell dysfunction and …
Differentiating drusen: Drusen and drusen-like appearances associated with ageing, age-related macular degeneration, inherited eye disease and other pathological …
Drusen are discussed frequently in the context of their association with age-related macular
degeneration (AMD). Some types may, however, be regarded as a normal consequence of …
degeneration (AMD). Some types may, however, be regarded as a normal consequence of …