Midbrain dopaminergic (mDA) neuron development has been an intense area of research
during recent years. This is due in part to a growing interest in regenerative medicine and …

The roles of the Wnt signalling pathway in several developmental processes, including
synaptic differentiation, are well characterized. The expression of Wnt ligands and Wnt …

The long-term goal of nuclear transfer or alternative reprogramming approaches is to create
patient-specific donor cells for transplantation therapy, avoiding immunorejection, a major …

A common hallmark of age‐dependent neurodegenerative diseases is an impairment of
adult neurogenesis. Wingless‐type mouse mammary tumor virus integration site (Wnt)/β …

Stem cell–based approaches have received much hype as potential treatments for
neurodegenerative disorders. Indeed, transplantation of stem cells or their derivatives in …

In a substantial fraction of prostate cancer (PCa) patients, bone metastasis appears after
years or even decades of latency. Canonical Wnt/β-catenin signaling has been proposed to …

Parkinson disease (PD) is a neurodegenerative disorder characterized by dopaminergic
neurons affected by inflammatory processes. Post-mortem analyses of brain and …

Neural stem/progenitor cells (NSCs) maintain the ability of self-renewal and differentiation
and compose the complex nervous system. Wnt signaling is thought to control the balance of …

The receptor class Frizzled, which has recently been categorized as a separate group of G
protein-coupled receptors by the International Union of Basic and Clinical Pharmacology …

Lifelong neurogenesis and incorporation of newborn neurons into mature neuronal circuits
operates in specialized niches of the mammalian brain and serves as role model for …