Non-alcoholic fatty liver disease (NAFLD) pathogenesis and natural products for prevention and treatment

X Guo, X Yin, Z Liu, J Wang - International journal of molecular sciences, 2022 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease,
affecting approximately one-quarter of the global population, and has become a world public …

Reactivity of metal–oxo clusters towards biomolecules: from discrete polyoxometalates to metal–organic frameworks

DES Marcano, ND Savić, K Declerck… - Chemical Society …, 2024 - pubs.rsc.org
Metal–oxo clusters hold great potential in several fields such as catalysis, materials science,
energy storage, medicine, and biotechnology. These nanoclusters of transition metals with …

[HTML][HTML] Lipid-laden lung mesenchymal cells foster breast cancer metastasis via metabolic reprogramming of tumor cells and natural killer cells

Z Gong, Q Li, J Shi, ET Liu, LD Shultz, G Ren - Cell metabolism, 2022 - cell.com
While the distant organ environment is known to support metastasis of primary tumors, its
metabolic roles in this process remain underdetermined. Here, in breast cancer models, we …

A lipase-independent pathway of lipid release and immune modulation by adipocytes

SE Flaherty III, A Grijalva, X Xu, E Ables, A Nomani… - Science, 2019 - science.org
To meet systemic metabolic needs, adipocytes release fatty acids and glycerol through the
action of neutral lipases. Here, we describe a secondary pathway of lipid release from …

The biophysics and cell biology of lipid droplets

AR Thiam, RV Farese Jr, TC Walther - Nature reviews Molecular cell …, 2013 - nature.com
Lipid droplets are intracellular organelles that are found in most cells, where they have
fundamental roles in metabolism. They function prominently in storing oil-based reserves of …

Understanding the factors that effect maximal fat oxidation

T Purdom, L Kravitz, K Dokladny… - Journal of the …, 2018 - Taylor & Francis
Lipids as a fuel source for energy supply during submaximal exercise originate from
subcutaneous adipose tissue derived fatty acids (FA), intramuscular triacylglycerides (IMTG) …

Perilipins: a diversity of intracellular lipid droplet proteins

H Itabe, T Yamaguchi, S Nimura, N Sasabe - Lipids in health and disease, 2017 - Springer
Intracellular lipid droplets (LDs) are found in a wide variety of cell types and have been
recognized as organelles with unique spherical structures. Although LDs are not stable lipid …

Regulation of mammalian autophagy in physiology and pathophysiology

B Ravikumar, S Sarkar, JE Davies… - Physiological …, 2010 - journals.physiology.org
(Macro) autophagy is a bulk degradation process that mediates the clearance of long-lived
proteins and organelles. Autophagy is initiated by double-membraned structures, which …

[HTML][HTML] Acyl-lipid metabolism

Y Li-Beisson, B Shorrosh, F Beisson… - The Arabidopsis book …, 2013 - ncbi.nlm.nih.gov
Acyl lipids in Arabidopsis and all other plants have a myriad of diverse functions. These
include providing the core diffusion barrier of the membranes that separates cells and …

Insect fat body: energy, metabolism, and regulation

EL Arrese, JL Soulages - Annual review of entomology, 2010 - annualreviews.org
The fat body plays major roles in the life of insects. It is a dynamic tissue involved in multiple
metabolic functions. One of these functions is to store and release energy in response to the …