Crystallinity: a complex critical quality attribute of amorphous solid dispersions
DE Moseson, LS Taylor - Molecular Pharmaceutics, 2023 - ACS Publications
Does the performance of an amorphous solid dispersion rely on having 100% amorphous
content? What specifications are appropriate for crystalline content within an amorphous …
content? What specifications are appropriate for crystalline content within an amorphous …
[HTML][HTML] The biomolecular gastrointestinal corona in oral drug delivery
The formation of a biomolecular corona on exogenous particles in plasma is well studied
and is known to dictate the biodistribution and cellular interactions of nanomedicine …
and is known to dictate the biodistribution and cellular interactions of nanomedicine …
A computational-based approach to fabricate Ceritinib co-amorphous system using a novel co-former Rutin for bioavailability enhancement
In this study, we used molecular simulations to design Ceritinib (CRT) co-amorphous
materials (CAMs) with concurrent improvement in solubility and bioavailability …
materials (CAMs) with concurrent improvement in solubility and bioavailability …
Influences of crystal anisotropy in pharmaceutical process development
E Hadjittofis, MA Isbell, V Karde, S Varghese… - Pharmaceutical …, 2018 - Springer
Crystalline materials are of crucial importance to the pharmaceutical industry, as a large
number of APIs are formulated in crystalline form, occasionally in the presence of crystalline …
number of APIs are formulated in crystalline form, occasionally in the presence of crystalline …
Recent advances in enhancement of dissolution and supersaturation of poorly water-soluble drug in amorphous pharmaceutical solids: A review
Q Shi, F Li, S Yeh, SM Moinuddin, J Xin, J Xu… - Aaps Pharmscitech, 2022 - Springer
Amorphization is one of the most effective pharmaceutical approaches to enhance the
dissolution and oral bioavailability of poorly water-soluble drugs. In recent years, amorphous …
dissolution and oral bioavailability of poorly water-soluble drugs. In recent years, amorphous …
Phase behavior and crystallization kinetics of a poorly water-soluble weakly basic drug as a function of supersaturation and media composition
T Van Duong, Z Ni, LS Taylor - Molecular Pharmaceutics, 2022 - ACS Publications
Understanding the supersaturation and precipitation behavior of poorly water-soluble
compounds in vivo and the impact on oral absorption is critical to design consistently …
compounds in vivo and the impact on oral absorption is critical to design consistently …
A mechanistic review on the dissolution phase behavior and supersaturation stabilization of amorphous solid dispersions
P Ashwathy, AT Anto, MS Sudheesh - Drug Development and …, 2021 - Taylor & Francis
Amorphous solid dispersion (ASD) technology is an attractive formulation approach for
poorly soluble drugs because of the supersaturated state acquired during its dissolution …
poorly soluble drugs because of the supersaturated state acquired during its dissolution …
Paclitaxel crystal seeds with different intrinsic properties and their impact on dissolution of paclitaxel-HPMCAS amorphous solid dispersions
Dissolving a formulation containing the drug in amorphous form can lead to supersaturation
and increase the free drug concentration relative to that achieved by dissolving the …
and increase the free drug concentration relative to that achieved by dissolving the …
Designing synergistic crystallization inhibitors: Bile salt derivatives of cellulose with enhanced hydrophilicity
Crystallization inhibitors in amorphous solid dispersions (ASD) enable metastable
supersaturated drug solutions that persist for a physiologically relevant time. Olefin cross …
supersaturated drug solutions that persist for a physiologically relevant time. Olefin cross …
Impact of bile salt on solution-mediated phase transformation of pharmaceutical cocrystals: the importance of coformer release kinetics
J Chen, M Guo, R Fan, Y Peng, T Cai - Chemical Engineering Journal, 2022 - Elsevier
Cocrystal engineering has become increasingly prevalent as an efficient and versatile route
to overcome solubility limitations and improve the oral bioavailability of poorly soluble drugs …
to overcome solubility limitations and improve the oral bioavailability of poorly soluble drugs …