Antimalarial drug resistance in Africa: the calm before the storm?

MD Conrad, PJ Rosenthal - The Lancet Infectious Diseases, 2019 - thelancet.com
Antimalarial drug resistance, in particular resistance to Plasmodium falciparum, challenges
the treatment and control of malaria. In this Review, we summarise evolving patterns of …

Malaria epidemiology and interventions in Ethiopia from 2001 to 2016

HS Taffese, E Hemming-Schroeder… - Infectious diseases of …, 2018 - mednexus.org
Background: Ethiopia is one of the African countries where Plasmodium falciparum and P.
vivax co-exist. Monitoring and evaluation of current malaria transmission status is an …

Plasmodium falciparum resistant to artemisinin and diagnostics have emerged in Ethiopia

AA Fola, SM Feleke, H Mohammed, BG Brhane… - Nature …, 2023 - nature.com
Diagnosis and treatment of Plasmodium falciparum infections are required for effective
malaria control and are pre-requisites for malaria elimination efforts; hence we need to …

[HTML][HTML] A review of the frequencies of Plasmodium falciparum Kelch 13 artemisinin resistance mutations in Africa

L Ndwiga, KM Kimenyi, K Wamae, V Osoti… - International Journal for …, 2021 - Elsevier
Artemisinin resistance (AR) emerged in South East Asia 13 years ago and the identification
of the resistance conferring molecular marker, Plasmodium falciparum Kelch 13 (Pfk13), 7 …

[HTML][HTML] Monitoring Plasmodium vivax resistance to antimalarials: Persisting challenges and future directions

MU Ferreira, TN de Sousa, GW Rangel… - International Journal for …, 2021 - Elsevier
Emerging antimalarial drug resistance may undermine current efforts to control and
eliminate Plasmodium vivax, the most geographically widespread yet neglected human …

Genomic analysis of Plasmodium vivax describes patterns of connectivity and putative drivers of adaptation in Ethiopia

AM Kebede, E Sutanto, H Trimarsanto… - Scientific Reports, 2023 - nature.com
Ethiopia has the greatest burden of Plasmodium vivax in Africa, but little is known about the
epidemiological landscape of parasites across the country. We analysed the genomic …

Use cases for genetic epidemiology in malaria elimination

R Dalmat, B Naughton, TS Kwan-Gett, J Slyker… - Malaria journal, 2019 - Springer
Background While traditional epidemiological approaches have supported significant
reductions in malaria incidence across many countries, higher resolution information about …

Genomic Analysis of Plasmodium vivax in Southern Ethiopia Reveals Selective Pressures in Multiple Parasite Mechanisms

S Auburn, S Getachew, RD Pearson… - The Journal of …, 2019 - academic.oup.com
Abstract The Horn of Africa harbors the largest reservoir of Plasmodium vivax in the
continent. Most of sub-Saharan Africa has remained relatively vivax-free due to a high …

Diversity and Multiplicity of P. falciparum infections among asymptomatic school children in Mbita, Western Kenya

AO Touray, VA Mobegi, F Wamunyokoli, JK Herren - Scientific reports, 2020 - nature.com
Multiplicity of infection (MOI) and genetic diversity of P. falciparum infections are important
surrogate indicators for assessing malaria transmission intensity in different regions of …

High prevalence of Pfcrt 76T and Pfmdr1 N86 genotypes in malaria infected patients attending health facilities in East Shewa zone, Oromia Regional State, Ethiopia

J Hassen, GS Alemayehu, H Dinka, L Golassa - Malaria Journal, 2022 - Springer
Background Plasmodium falciparum resistance to series of anti-malarial drugs is a major
challenge in efforts to control and/or eliminate malaria globally. In 1998, following the …