Potato (Solanum tuberosum L.) is the world's most important non-cereal food crop, and the
vast majority of commercially grown cultivars are highly heterozygous tetraploids. Advances …

Fungal microorganisms (mycobiota) comprise a small but immunoreactive component of the
human microbiome, yet little is known about their role in human cancers. Pan-cancer …

How enhancers control target gene expression over long genomic distances remains an
important unsolved problem. Here we investigated enhancer–promoter communication by …

The engineering of autologous patient T cells for adoptive cell therapies has revolutionized
the treatment of several types of cancer. However, further improvements are needed to …

Abstract The Farm Animal Genotype-Tissue Expression (FarmGTEx) project has been
established to develop a public resource of genetic regulatory variants in livestock, which is …

Abstract γδ T cells are potent anticancer effectors with the potential to target tumours
broadly, independent of patient-specific neoantigens or human leukocyte antigen …

The centromere represents a single region in most eukaryotic chromosomes. However,
several plant and animal lineages assemble holocentromeres along the entire chromosome …

Summary CD137 (4-1BB)-activating receptor represents a promising cancer
immunotherapeutic target. Yet, the cellular program driven by CD137 and its role in cancer …

The forthcoming massive genome data generated by the Earth BioGenome Project will open
up a new era of comparative genomics, for which genome synteny analysis provides an …

Chromosome conformation capture data, particularly from high-throughput approaches such
as Hi-C, are typically very complex to analyse. Existing analysis tools are often single …