A rate-limiting step in the prevention and early intervention of depressive disorders in young
people is our insufficient understanding of causal mechanisms. One plausible …

Abstract Although the GABAergic benzodiazepines (BZDs) and Z-drugs (zolpidem,
zopiclone, and zaleplon) are FDA-approved for insomnia disorders with a strong evidence …

Sleep and circadian rhythm disruption are frequently observed in patients with psychiatric
disorders and neurodegenerative disease. The abnormal sleep that is experienced by these …

Benzodiazepine sedative‐hypnotic drugs are widely used for the treatment of insomnia.
Nevertheless, their adverse effects, such as next‐day hangover, dependence and …

Significance: Our current knowledge of the pathophysiology and molecular mechanisms
causing psychiatric disorders is modest, but genetic susceptibility and environmental factors …

Macrophages and their counterparts in the central nervous system, the microglia, detect and
subsequently clear microbial pathogens and injured tissue. These phagocytic cells alter and …

Major depression is one of the leading causes of premature death and disability. Although
available drugs are effective, they also have substantial limitations. Recent advances in our …

Major mood syndromes are among the most common and disabling mental disorders.
However, a lack of clear delineation of their underlying pathophysiological mechanisms is a …

Objective To systematically review published and unpublished efficacy studies of
agomelatine in people with depression. Design Systematic review and meta-analysis. Data …

Background Actigraphy has enabled consecutive observation of individual health conditions
such as sleep or daily activity. This study aimed to examine the usefulness of actigraphy in …