Biological activity of oxadiazole and thiadiazole derivatives

UA Atmaram, SM Roopan - Applied Microbiology and Biotechnology, 2022 - Springer
The 5-membered oxadiazole and thiadiazole scaffolds are the most privileged and well-
known heterocycles, being a common and essential feature of a variety of natural products …

Exploring recent developments on 1, 2, 4‐triazole: Synthesis and biological applications

R Sathyanarayana, B Poojary - Journal of the Chinese …, 2020 - Wiley Online Library
Triazoles are nitrogen‐bearing heterocycles. In the last few decades, researchers have
focused on fused heterocycles, as they have better pharmacological effect compared to …

Induction of apoptosis and antiproliferative activity of naringenin in human epidermoid carcinoma cell through ROS generation and cell cycle arrest

MS Ahamad, S Siddiqui, A Jafri, S Ahmad, M Afzal… - PloS one, 2014 - journals.plos.org
A natural predominant flavanone naringenin, especially abundant in citrus fruits, has a wide
range of pharmacological activities. The search for antiproliferative agents that reduce skin …

Development of adamantane scaffold containing 1, 3, 4-thiadiazole derivatives: Design, synthesis, anti-proliferative activity and molecular docking study targeting …

MMS Wassel, YA Ammar, GAME Ali, A Belal… - Bioorganic …, 2021 - Elsevier
Abstract A new series of 1, 3, 4-thiadiazolo-adamantane derivatives were synthesized
through molecular hybridization approach, then used as starting material to synthesize …

Anticancer and Antioxidant activity of Zingiber officinale Roscoe rhizome

JA Ansari, MK Ahmad, AR Khan, N Fatima, HJ Khan… - 2016 - nopr.niscpr.res.in
Dietary components present in foods, spices and herbs are source of natural compounds
viz. phenols, flavonoids, tocopherols, ascorbic acid and carotenoids with potential benefits …

Effectual anticancer potentiality of loaded bee venom onto fungal chitosan nanoparticles

AI Alalawy, HA El Rabey, FM Almutairi… - … journal of polymer …, 2020 - Wiley Online Library
Chitosan and its nanoparticles (NPs) could be extracted from numerous fungal species and
used as effectual carriers for bioactive compounds. The fungal chitosan (FC) was …

Recent development of 1, 2, 4-triazole-containing compounds as anticancer agents

X Wen, Y Zhou, J Zeng, X Liu - Current Topics in Medicinal …, 2020 - ingentaconnect.com
1, 2, 4-Triazole derivatives possess promising in vitro and in vivo anticancer activity, and
many anticancer agents such as fluconazole, tebuconazole, triadimefon, and ribavirin bear a …

Unveiling the chemistry of 1, 3, 4‐oxadiazoles and thiadiazols: A comprehensive review

VK Gour, S Yahya, M Shahar Yar - Archiv der Pharmazie, 2024 - Wiley Online Library
Oxadiazoles and thiadiazoles are malleable heterocycles that have recently generated
major interest in the field of medicinal chemistry. Compounds based on these moieties have …

[HTML][HTML] Synthesis and anticancer activity of novel 3, 6-disubstituted 1, 2, 4-triazolo-[3, 4-b]-1, 3, 4-thiadiazole derivatives

G Charitos, DT Trafalis, P Dalezis, C Potamitis… - Arabian Journal of …, 2019 - Elsevier
The development of new antitumor agents is one of the most pressing research areas in
medicinal chemistry and medicine. The importance of triazole and thiadiazole rings as …

New fluorinated diarylureas linked to pyrrolo [2, 3-d] pyrimidine scaffold as VEGFR-2 inhibitors: Molecular docking and biological evaluation

M Adel, KAM Abouzid - Bioorganic Chemistry, 2022 - Elsevier
Abstract A series of pyrrolo [2, 3-d] pyrimidine linked to diarylureas were previously
discovered by our group as sorafenib fused congeners, which were endowed with more …