mRNA-based therapeutics: powerful and versatile tools to combat diseases

S Qin, X Tang, Y Chen, K Chen, N Fan… - Signal transduction and …, 2022 - nature.com
The therapeutic use of messenger RNA (mRNA) has fueled great hope to combat a wide
range of incurable diseases. Recent rapid advances in biotechnology and molecular …

mRNA vaccine era—mechanisms, drug platform and clinical prospection

S Xu, K Yang, R Li, L Zhang - International journal of molecular sciences, 2020 - mdpi.com
Messenger ribonucleic acid (mRNA)-based drugs, notably mRNA vaccines, have been
widely proven as a promising treatment strategy in immune therapeutics. The extraordinary …

The challenge and prospect of mRNA therapeutics landscape

Y Weng, C Li, T Yang, B Hu, M Zhang, S Guo… - Biotechnology …, 2020 - Elsevier
Messenger RNA (mRNA)-based therapeutics hold the potential to cause a major revolution
in the pharmaceutical industry because they can be used for precise and individualized …

[HTML][HTML] From COVID-19 to cancer mRNA vaccines: moving from bench to clinic in the vaccine landscape

C Chakraborty, AR Sharma, M Bhattacharya… - Frontiers in …, 2021 - frontiersin.org
Recently, mRNA vaccines have become a significant type of therapeutic and have created
new fields in the biopharmaceutical industry. mRNA vaccines are promising next-generation …

Metabolic communication during exercise

RM Murphy, MJ Watt, MA Febbraio - Nature metabolism, 2020 - nature.com
The coordination of nutrient sensing, delivery, uptake and utilization is essential for
maintaining cellular, tissue and whole-body homeostasis. Such synchronization can be …

mRNA-based vaccines and therapeutics: an in-depth survey of current and upcoming clinical applications

YS Wang, M Kumari, GH Chen, MH Hong… - Journal of Biomedical …, 2023 - Springer
Abstract mRNA-based drugs have tremendous potential as clinical treatments, however, a
major challenge in realizing this drug class will promise to develop methods for safely …

Sarcopenia in chronic kidney disease: factors, mechanisms, and therapeutic interventions

H Watanabe, Y Enoki, T Maruyama - Biological and Pharmaceutical …, 2019 - jstage.jst.go.jp
Chronic kidney disease (CKD), a chronic catabolic condition, is characterized by muscle
wasting and decreased muscle endurance. Many insights into the molecular mechanisms of …

[HTML][HTML] mRNA cancer vaccines: Advances, trends and challenges

Q He, H Gao, D Tan, H Zhang, J Wang - Acta Pharmaceutica Sinica B, 2022 - Elsevier
Patients exhibit good tolerance to messenger ribonucleic acid (mRNA) vaccines, and the
choice of encoded molecules is flexible and diverse. These vaccines can be engineered to …

[PDF][PDF] The roles of polymers in mRNA delivery

P Huang, H Deng, Y Zhou, X Chen - Matter, 2022 - cell.com
Summary mRNA therapy, which possesses distinctive advantages over DNA and protein-
based therapies, has immense potential for diverse applications, including mRNA vaccines …

Synthetic modified messenger RNA for therapeutic applications

M Gao, Q Zhang, XH Feng, J Liu - Acta biomaterialia, 2021 - Elsevier
Synthetic modified messenger RNA (mRNA) has manifested great potentials for therapeutic
applications such as vaccines and gene therapies, with the recent mRNA vaccines for global …