The regulation of antibody production is linked to the generation and maintenance of
plasmablasts and plasma cells from their B cell precursors. Plasmablasts are the rapidly …

Humoral immunity depends on the germinal centre (GC) reaction during which somatically
mutated high-affinity memory B cells and plasma cells are generated. Recent studies have …

Background Abundant evidence shows that triple-negative breast cancer (TNBC) is
heterogeneous, and many efforts have been devoted to identifying TNBC subtypes on the …

Memory B cells (MBCs) are critical for the rapid development of protective immunity
following re-infection. MBCs capable of neutralizing distinct subclasses of pathogens, such …

Despite the importance of memory B cells in protection from reinfection, how such memory
cells are selected and generated during germinal-center (GC) reactions remains unclear …

Summary Interferon regulatory factor-8 (IRF8) has been proposed to be essential for
development of monocytes, plasmacytoid dendritic cells (pDCs) and type 1 conventional …

In lupus, Toll-like receptor 7 (TLR7) and TLR9 mediate loss of tolerance to RNA and DNA,
respectively. Yet, TLR7 promotes disease, while TLR9 protects from disease, implying …

Plasma cells (PCs) are responsible for the production of protective antibodies against
infectious agents but they also produce pathogenic antibodies in autoimmune diseases …

Age-associated B cells (ABCs) are a subset of B cells dependent on the transcription factor T-
bet that accumulate prematurely in autoimmune settings. The pathways that regulate ABCs …

The genomic loci associated with B cell differentiation that are subject to transcriptional and
epigenetic regulation in vivo are not well defined, leaving a gap in our understanding of the …