The endothelium can evoke relaxations of the underlying vascular smooth muscle, by
releasing vasodilator substances. The best‐characterized endothelium‐derived relaxing …

In this review we examine the effects of both over-and under-production of heme oxygenase-
1 (HO-1) and HO activity on a broad spectrum of biological systems and on vascular …

Aims Endothelial‐derived epoxyeicosatrienoic acids may regulate vascular tone and are
metabolized by soluble epoxide hydrolase enzymes (sEH). GSK2256294 is a potent and …

Short chain fatty acids (SCFAs), a family of gut microbial metabolites, have been reported to
promote preservation of endothelial function and thereby exert anti-atherosclerotic action …

The global epidemic of obesity continues unabated with sequelae of diabetes and metabolic
syndrome. This review reflects the dramatic increase in research on the role of increased …

Background/objectives Obesity is a risk factor in the development of type 2 diabetes mellitus
(DM2), which is associated with increased morbidity and mortality, predominantly as a result …

Cytochrome P450 2J2 (CYP2J2) is a known arachidonic acid (AA) epoxygenase that
mediates the formation of four bioactive regioisomers of cis-epoxyeicosatrienoic acids …

Epoxyeicosatrienoic acid (EET) contributes to browning of white adipose stem cells to
ameliorate obesity/diabetes and insulin resistance. In the current study, we show that EET …

Vasculopathy is a major complication of diabetes. Impaired mitochondrial bioenergetics and
biogenesis due to oxidative stress are a critical causal factor for diabetic endothelial …

Background Oxidative stress underlies the etiopathogenesis of nonalcoholic fatty liver
disease (NAFLD), obesity and cardiovascular disease (CVD). Heme Oxygenase-1 (HO-1) is …