Interspersed repetitions called transposable elements (TEs), commonly referred to as mobile
elements, make up a significant portion of the genomes of higher animals. TEs contribute in …

Approximately 45% of the human genome is composed of transposable elements (TEs).
Expression of these elements is tightly regulated during normal development. TEs may be …

The long-term remissions induced by immune-checkpoint inhibitors (ICIs) in many types of
cancers have opened up the possibility of a broader use of immunotherapy in less …

Most living organisms have in their genome a sizable proportion of DNA sequences capable
of mobilization; these sequences are commonly referred to as transposons, transposable …

Ovarian cancer is the most lethal gynecologic malignancy. Platinum-based chemotherapy is
the backbone of treatment for ovarian cancer, and although the majority of patients initially …

Background DNA mismatch repair proficient (pMMR) metastatic colorectal cancer (mCRC) is
not responsive to pembrolizumab monotherapy. DNA methyltransferase inhibitors can …

In recent years, the tumour microenvironment (TME) of solid tumours has attracted more and
more attention from researchers, especially those non-tumour components such as immune …

Advanced and recurrent gynecological cancers are associated with a poor prognosis and
there is still a lack of effective treatments. Immune checkpoint blockade (ICB) therapy is an …

Cancer immunotherapy using immune-checkpoint inhibitors (ICIs) has revolutionized the
field of cancer treatment; however, ICI efficacy is constrained by progressive dysfunction of …

Over the last two decades, several epi‐drugs, immune checkpoint inhibitors (ICIs) and
adoptive cell therapies have received clinical approval for use in certain types of cancer …