Maintaining optimal mitochondrial function is a feature of health. Mitophagy removes and
recycles damaged mitochondria and regulates the biogenesis of new, fully functional ones …

Coronaviruses (CoVs) are by far the largest group of known positive‐sense RNA viruses
having an extensive range of natural hosts. In the past few decades, newly evolved …

Autophagy, a multistep lysosomal degradation pathway that supports nutrient recycling and
metabolic adaptation, has been implicated as a process that regulates cancer. Although …

BACKGROUND As the world population ages, chronic diseases such as diabetes,
cardiovascular disease, cancer, and neurodegeneration become ever more prevalent …

These guidelines are a consensus work of a considerable number of members of the
immunology and flow cytometry community. They provide the theory and key practical …

From a technical point of view a flow cytometer is a light detection device capable of
detecting photons of different wavelengths over a high dynamic range. In order to achieve a …

This article reviews the development of the immune response through neonatal, infant and
adult life, including pregnancy, ending with the decline in old age. A picture emerges of a …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

Failure to make adaptive immune responses is a hallmark of aging. Reduced B cell function
leads to poor vaccination efficacy and a high prevalence of infections in the elderly. Here we …

Throughout life, the T cell system adapts to shifting resources and demands, resulting in a
fundamentally restructured immune system in older individuals. Here we review the cellular …