Aromatase inhibitors: A new approach for controlling ovarian function in cattle

MJ Yapura, EM Zwiefelhofer, RA Pierson, GP Adams - Theriogenology, 2018 - Elsevier
Numerous treatments and protocols have been used to control the reproductive cycle in
cattle, with varying effectiveness and many involving the administration of steroid hormones …

The pharmacokinetics of letrozole and its effect on gonadotropins in anestrous ewes

MB Kivrak, O Corum, H Alkan, O Atik, I Aydin, K Uney - Theriogenology, 2021 - Elsevier
The aim of this study was to determine the pharmacokinetics of letrozole and its effect on
FSH and LH concentrations after single (IV, IM, SC) and repeated IV doses in anestrous …

Pharmacokinetics of letrozole and effects of its increasing doses on gonadotropins in ewes during the breeding season

MB Kivrak, O Corum, M Yuksel, E Turk… - Journal of Veterinary …, 2024 - Wiley Online Library
Letrozole is a non‐steroidal, third‐generation aromatase inhibitor used in humans. Although
letrozole is not approved for use in animals, it is used off‐label in cases of synchronization …

Effects of letrozole administration on growth and reproductive performance in Markhoz goat bucklings

A Rezaei, A Vaziry, A Farshad, A Farzinpour… - Theriogenology, 2020 - Elsevier
This study evaluated the growth performance, testicular and semen characteristics, and
hormonal profile of Markhoz (Iranian Angora) bucklings injected with letrozole (LTZ). Twenty …

Research and development of a silicone letrozole-releasing device to control reproduction in cattle

EM Zwiefelhofer, BM Davis, GP Adams - Theriogenology, 2020 - Elsevier
Two experiments were conducted to test the effectiveness of a silicone matrix as an
intravaginal drug delivery device for letrozole, an aromatase inhibitor used for …

[HTML][HTML] Administration of aromatase inhibitor MPV-2213ad to blue fox vixens (Vulpes lagopus) as a model for contraception in female dogs

L Lindh, H Lindeberg, A Banting, S Banting, S Sainmaa… - Theriogenology, 2020 - Elsevier
The interest in non-surgical approaches to contraception and fertility control in female dogs
has increased in recent years. In this study the effect of an aromatase inhibitor (finrozole) …

Synchronization of ovulation in cattle with an aromatase inhibitor–based protocol

MJ Yapura, RJ Mapletoft, RA Pierson, J Singh… - Theriogenology, 2016 - Elsevier
A study was designed to determine the effect of stage of the estrous cycle on the proportion
of animals that ovulated and the synchrony of ovulation of heifers treated with an aromatase …

An attempt to potentiate the ovarian superstimulatory response in cattle by co-treatment with an aromatase inhibitor

EM Zwiefelhofer, RJ Mapletoft, GP Adams - Theriogenology, 2020 - Elsevier
Letrozole is used for the treatment of subfertility in women undergoing ovarian
superstimulation, but the mechanism of action has not been investigated critically. The …

Formulation and testing of a non-steroidal aromatase inhibitor intravaginal device for the control of ovarian function in cattle

J Yapura, I Badea, G Zamberlam, C Price… - Animal reproduction …, 2015 - Elsevier
The study was designed to formulate intravaginal devices that provide biologically active
circulating concentrations of an aromatase inhibitor for a minimum of 4 days, and to …

The effects of preovulatory administration of oral letrozole on ovulatory follicle and the subsequent corpus luteum in mares

V Akbarinejad, F Gharagozlou… - Comparative Clinical …, 2017 - Springer
Progesterone acts as an important factor in maintenance of pregnancy and development of
equine embryo. Treatment with letrozole, a nonsteroidal inhibitor of aromatase enzyme …