[2+ 2]-Cycloaddition-derived cyclobutane natural products: structural diversity, sources, bioactivities, and biomimetic syntheses

P Yang, Q Jia, S Song, X Huang - Natural Product Reports, 2023 - pubs.rsc.org
Covering: up to the end of 2021 [2+ 2]-Type cyclobutane natural products are
biosynthetically derived from intermolecular [2+ 2] cycloaddition or intramolecular [2+ 2] …

Underlying anticancer mechanisms and synergistic combinations of phytochemicals with cancer chemotherapeutics: potential benefits and risks

M Ayaz, A Nawaz, S Ahmad, OF Mosa… - Journal of Food …, 2022 - Wiley Online Library
Cancer therapies are associated with various challenges including the emergence of
multidrug resistant tumors, toxicological issues, severe side effects, and economic burden …

Network pharmacology and molecular docking reveal the mechanism of Scopoletin against non-small cell lung cancer

C Yuan, MH Wang, F Wang, PY Chen, XG Ke, B Yu… - Life sciences, 2021 - Elsevier
Aims Scopoletin is a natural anticarcinogenic and antiviral coumarin component. Many
studies have proved its anti-cancer effect, and after the preliminary screening of this study …

The role of machine learning and deep learning approaches for the detection of skin cancer

T Mazhar, I Haq, A Ditta, SAH Mohsan, F Rehman… - Healthcare, 2023 - mdpi.com
Machine learning (ML) can enhance a dermatologist's work, from diagnosis to customized
care. The development of ML algorithms in dermatology has been supported lately …

HPLC, FTIR and GC-MS Analyses of Thymus vulgaris Phytochemicals Executing In Vitro and In Vivo Biological Activities and Effects on COX-1, COX-2 and Gastric …

A Saleem, M Afzal, M Naveed, SI Makhdoom… - Molecules, 2022 - mdpi.com
Medicinal plants have played an essential role in the treatment of various diseases. Thymus
vulgaris, a medicinal plant, has been extensively used for biological and pharmaceutical …

A Comprehensive In Silico Exploration of Pharmacological Properties, Bioactivities, Molecular Docking, and Anticancer Potential of Vieloplain F from Xylopia vielana …

SS Hassan, SQ Abbas, F Ali, M Ishaq, I Bano… - Molecules, 2022 - mdpi.com
Compounds derived from plants have several anticancer properties. In the current study,
one guaiane-type sesquiterpene dimer, vieloplain F, isolated from Xylopia vielana species …

Stress driven discovery of natural products from actinobacteria with anti-oxidant and cytotoxic activities including docking and admet properties

SS Hassan, I Muhammad, SQ Abbas… - International Journal of …, 2021 - mdpi.com
Elicitation through abiotic stress, including chemical elicitors like heavy metals, is a new
technique for drug discovery. In this research, the effect of heavy metals on actinobacteria …

Anti-Inflammatory, Analgesic and Antioxidant Potential of New (2S,3S)-2-(4-isopropylbenzyl)-2-methyl-4-nitro-3-phenylbutanals and Their Corresponding Carboxylic …

F Mahmood, JA Khan, MH Mahnashi, MS Jan… - Molecules, 2022 - mdpi.com
In the current study, a series of new (2 S, 3 S)-2-(4-isopropylbenzyl)-2-methyl-4-nitro-3-
phenylbutanals (FM1-6) with their corresponding carboxylic acid analogues (FM7-12) has …

Comprehensive Phytochemical Profiling, Biological Activities, and Molecular Docking Studies of Pleurospermum candollei: An Insight into Potential for Natural …

M Ahmed, KR Khan, S Ahmad, HY Aati, C Ovatlarnporn… - Molecules, 2022 - mdpi.com
The purpose of this study was to find the biological propensities of the vegetable plant
Pleurospermum candollei by investigating its phytochemical profile and biological activities …

Anti-diabetic Activity of Brucine in Streptozotocin-Induced Rats: In Silico, In Vitro, and In Vivo Studies

NU Khan, NG Qazi, A Khan, F Ali, SS Hassan… - ACS …, 2022 - ACS Publications
Diabetes mellitus (DM) is a complex and multiple group of disorders, and understanding the
molecular mechanisms is a key role in identifying various markers involved in the diagnosis …