As a result of metabolic reprogramming, cancer cells display high rates of glycolysis,
causing an excess production of lactate along with an increase in extracellular acidity …

It is widely accepted that the gut microbiota plays a significant role in modulating
inflammatory and immune responses of their host. In recent years, the host-microbiota …

Background In order to correctly decode phenotypic information from RNA-sequencing
(RNA-seq) data, careful selection of the RNA-seq quantification measure is critical for inter …

MVI has significant clinical value for treatment selection and prognosis evaluation in
hepatocellular carcinoma (HCC). We aimed to construct a model based on MVI-Related …

N6-methyladenosine RNA modification plays a significant role in the progression of multiple
tumorigenesis. Our study identified the imperative role of m6A regulators in the tumor …

The human aging process is associated with molecular changes and cellular degeneration,
resulting in a significant increase in cancer incidence with age. Despite their potential …

Osteosarcoma (OS) is the most common type of primary malignant bone tumor. The high-
throughput sequencing technology has shown potential abilities to illuminate the pathogenic …

Background: Previous studies revealed that colonic cancer-associated fibroblasts (CAFs)
are associated with the modulation of the colon tumor microenvironment (TME). However …

Background Currently, lung adenocarcinoma is the most common form of lung cancer.
Although the pathogenesis of lung adenocarcinoma is progressing rapidly, the mortality rate …

Metabolic compartmentalization of stroma-rich tumors, like pancreatic ductal
adenocarcinoma (PDAC), greatly contributes to malignancy. This involves cancer cells …