Cathepsin B (CatB), a cysteine protease, is primarily localized within subcellular endosomal
and lysosomal compartments. It is involved in the turnover of intracellular and extracellular …

Cysteine cathepsin protease activity is frequently dysregulated in the context of neoplastic
transformation. Increased activity and aberrant localization of proteases within the tumour …

Lysosomes are ubiquitous membrane-bound intracellular organelles with an acidic interior.
They are central for degradation and recycling of macromolecules delivered by endocytosis …

Lysosomes serve as the cellular recycling centre and are filled with numerous hydrolases
that can degrade most cellular macromolecules. Lysosomal membrane permeabilization …

A single mouse click on the topic tumor necrosis factor (TNF) in PubMed reveals about 50
000 articles providing one or the other information about this pleiotropic cytokine or its …

Mitochondrial outer membrane permeabilization (MOMP) constitutes one of the major
checkpoint (s) of apoptotic and necrotic cell death. Recently, the permeabilization of yet …

Because of its unique function and anatomical location, the liver is exposed to a multitude of
toxins and xenobiotics, including medications and alcohol, as well as to infection by …

Inflammation is an adaptive response in pursuit of homeostasis reestablishment triggered by
harmful conditions or stimuli, such as an infection or tissue damage. Liver diseases cause …

Lysosomal hydrolases participate in the digestion of endocytosed and autophagocytosed
material inside the lysosomal/autolysosomal compartment in acute cell death when released …

Cysteine proteases continue to provide validated targets for treatment of human diseases. In
neurodegenerative disorders, multiple cysteine proteases provide targets for enzyme …