[HTML][HTML] Mitochondrial oxidative stress in brain microvascular endothelial cells: Triggering blood-brain barrier disruption
Y Wang, J Wu, J Wang, L He, H Lai, T Zhang, X Wang… - Mitochondrion, 2023 - Elsevier
Blood-brain barrier disruption plays an important role in central nervous system diseases.
This review provides information on the role of mitochondrial oxidative stress in brain …
This review provides information on the role of mitochondrial oxidative stress in brain …
[HTML][HTML] Oxygen metabolism abnormality and Alzheimer's disease: An update
G Liu, C Yang, X Wang, X Chen, Y Wang, W Le - Redox Biology, 2023 - Elsevier
Oxygen metabolism abnormality plays a crucial role in the pathogenesis of Alzheimer's
disease (AD) via several mechanisms, including hypoxia, oxidative stress, and …
disease (AD) via several mechanisms, including hypoxia, oxidative stress, and …
Levistilide A ameliorates neuroinflammation via inhibiting JAK2/STAT3 signaling for neuroprotection and cognitive improvement in scopolamine-induced Alzheimer's …
H Ni, Y Liao, Y Zhang, H Lu, Z Huang, F Huang… - International …, 2023 - Elsevier
Alzheimer's disease (AD) is a progressive neurodegenerative disease associated with
cognitive impairment and dementia, which has become a major public health problem …
cognitive impairment and dementia, which has become a major public health problem …
[HTML][HTML] Inhibition of BACE1 attenuates microglia-induced neuroinflammation after intracerebral hemorrhage by suppressing STAT3 activation
J Zhuang, Y Cao, G Guo, M Li, T Zhang, D He… - Aging (Albany …, 2023 - ncbi.nlm.nih.gov
Hematoma-induced neuroinflammation is the cause of poor prognosis in intracerebral
hemorrhage (ICH); therefore, promoting blood clearance and blocking overactivated …
hemorrhage (ICH); therefore, promoting blood clearance and blocking overactivated …
Critical roles of protein disulfide isomerases in balancing proteostasis in the nervous system
DB Medinas, P Rozas, C Hetz - Journal of Biological Chemistry, 2022 - ASBMB
Protein disulfide isomerases (PDIs) constitute a family of oxidoreductases promoting redox
protein folding and quality control in the endoplasmic reticulum. PDIs catalyze disulfide bond …
protein folding and quality control in the endoplasmic reticulum. PDIs catalyze disulfide bond …
Common molecular signatures between coronavirus infection and Alzheimer's disease reveal targets for drug development
Background: Cognitive decline is a common consequence of COVID-19, and studies
suggest a link between COVID-19 and Alzheimer's disease (AD). However, the molecular …
suggest a link between COVID-19 and Alzheimer's disease (AD). However, the molecular …
Interleukin-22 Contributes to Blood–Brain Barrier Disruption via STAT3/VEGFA Activation in Escherichia coli Meningitis
R Yang, J Chen, X Qu, H Liu, X Wang… - ACS Infectious …, 2024 - ACS Publications
Escherichia coli continues to be the predominant Gram-negative pathogen causing neonatal
meningitis worldwide. Inflammatory mediators have been implicated in the pathogenesis of …
meningitis worldwide. Inflammatory mediators have been implicated in the pathogenesis of …
18 kDa translocator protein TSPO is a mediator of astrocyte reactivity
An increase in astrocyte reactivity has been described in Alzheimer's disease and seems to
be related to the presence of a pro-inflammatory environment. Reactive astrocytes show an …
be related to the presence of a pro-inflammatory environment. Reactive astrocytes show an …
Diffusion imaging genomics provides novel insight into early mechanisms of cerebral small vessel disease
Q Le Grand, A Tsuchida, A Koch, MA Imtiaz… - Molecular …, 2024 - nature.com
Cerebral small vessel disease (cSVD) is a leading cause of stroke and dementia. Genetic
risk loci for white matter hyperintensities (WMH), the most common MRI-marker of cSVD in …
risk loci for white matter hyperintensities (WMH), the most common MRI-marker of cSVD in …
Sex-specific transcriptional rewiring in the brain of Alzheimer's disease patients
JA Santiago, JP Quinn, JA Potashkin - Frontiers in Aging …, 2022 - frontiersin.org
Sex-specific differences may contribute to Alzheimer's disease (AD) development. AD is
more prevalent in women worldwide, and female sex has been suggested as a disease risk …
more prevalent in women worldwide, and female sex has been suggested as a disease risk …