Blood-brain barrier disruption plays an important role in central nervous system diseases.
This review provides information on the role of mitochondrial oxidative stress in brain …

Oxygen metabolism abnormality plays a crucial role in the pathogenesis of Alzheimer's
disease (AD) via several mechanisms, including hypoxia, oxidative stress, and …

Alzheimer's disease (AD) is a progressive neurodegenerative disease associated with
cognitive impairment and dementia, which has become a major public health problem …

Hematoma-induced neuroinflammation is the cause of poor prognosis in intracerebral
hemorrhage (ICH); therefore, promoting blood clearance and blocking overactivated …

Protein disulfide isomerases (PDIs) constitute a family of oxidoreductases promoting redox
protein folding and quality control in the endoplasmic reticulum. PDIs catalyze disulfide bond …

Background: Cognitive decline is a common consequence of COVID-19, and studies
suggest a link between COVID-19 and Alzheimer's disease (AD). However, the molecular …

Escherichia coli continues to be the predominant Gram-negative pathogen causing neonatal
meningitis worldwide. Inflammatory mediators have been implicated in the pathogenesis of …

An increase in astrocyte reactivity has been described in Alzheimer's disease and seems to
be related to the presence of a pro-inflammatory environment. Reactive astrocytes show an …

Cerebral small vessel disease (cSVD) is a leading cause of stroke and dementia. Genetic
risk loci for white matter hyperintensities (WMH), the most common MRI-marker of cSVD in …

Sex-specific differences may contribute to Alzheimer's disease (AD) development. AD is
more prevalent in women worldwide, and female sex has been suggested as a disease risk …