Abstract The RNA polymerase III (Pol III) transcriptome is universally comprised of short,
highly structured noncoding RNA (ncRNA). Through RNA–protein interactions, the Pol III …

Phosphatase and tensin homolog (PTEN) encodes a tumor-suppressive phosphatase with
both lipid and protein phosphatase activity. The tumor-suppressive functions of PTEN are …

Studying dynamic biological processes requires approaches compatible with the lifetimes of
the biochemical transactions under investigation, which can be very short. We describe a …

Osteoclasts (OCs), derived from monocyte/macrophage lineage, are key orchestrators in
bone remodeling. Targeting osteoclast apoptosis is a promising approach to cut down …

Recently, the potential use of nanoparticles for the targeted delivery of therapeutic and
diagnostic agents has garnered increased interest. Several nanoparticle drug delivery …

Vaults are ubiquitous ribonucleoprotein particles involved in a diversity of cellular
processes, with promising applications as nanodevices for delivery of multiple cargos. The …

PARP4 is an ADP-ribosyltransferase that resides within the vault ribonucleoprotein
organelle. Our knowledge of PARP4 structure and biochemistry is limited relative to other …

Simple Summary Small non-protein-coding RNAs have been recognized as valuable
regulators of gene expression in all three domains of life. Particularly in multicellular …

Vaccines have been used to train the immune system to recognize pathogens, and prevent
and treat diseases, such as cancer, for decades. However, there are continuing challenges …

Proteins have been widely used in the biomedical field because of their well-defined
architecture, accurate molecular weight, excellent biocompatibility and biodegradability, and …