A comparative view of metabolite and substrate stress and tolerance in microbial bioprocessing: from biofuels and chemicals, to biocatalysis and bioremediation
SA Nicolaou, SM Gaida, ET Papoutsakis - Metabolic engineering, 2010 - Elsevier
Metabolites, substrates and substrate impurities may be toxic to cells by damaging biological
molecules, organelles, membranes or disrupting biological processes. Chemical stress is …
molecules, organelles, membranes or disrupting biological processes. Chemical stress is …
Cellulosic hydrolysate toxicity and tolerance mechanisms in Escherichia coli
The sustainable production of biofuels will require the efficient utilization of lignocellulosic
biomass. A key barrier involves the creation of growth-inhibitory compounds by chemical …
biomass. A key barrier involves the creation of growth-inhibitory compounds by chemical …
Hyperproduction of 3-hydroxypropionate by Halomonas bluephagenesis
Hydroxypropionic acid (3HP), an important three carbon (C3) chemical, is designated as
one of the top platform chemicals with an urgent need for improved industrial production …
one of the top platform chemicals with an urgent need for improved industrial production …
Transcription factor-based screens and synthetic selections for microbial small-molecule biosynthesis
JA Dietrich, DL Shis, A Alikhani… - ACS synthetic …, 2013 - ACS Publications
Continued advances in metabolic engineering are increasing the number of small
molecules being targeted for microbial production. Pathway yields and productivities …
molecules being targeted for microbial production. Pathway yields and productivities …
Biosynthesis of platform chemical 3-hydroxypropionic acid (3-HP) directly from CO2 in cyanobacterium Synechocystis sp. PCC 6803
hydroxypropionic acid (3-HP) is an important platform chemical with a wide range of
applications. So far large-scale production of 3-HP has been mainly through petroleum …
applications. So far large-scale production of 3-HP has been mainly through petroleum …
Recent advances, challenges and metabolic engineering strategies in the biosynthesis of 3‐hydroxypropionic acid
B Liang, G Sun, X Zhang, Q Nie… - Biotechnology and …, 2022 - Wiley Online Library
As an attractive and valuable platform chemical, 3‐hydroxypropionic acid (3‐HP) can be
used to produce a variety of industrially important commodity chemicals and biodegradable …
used to produce a variety of industrially important commodity chemicals and biodegradable …
Mechanism of furfural toxicity and metabolic strategies to engineer tolerance in microbial strains
Lignocellulosic biomass represents a carbon neutral cheap and versatile source of carbon
which can be converted to biofuels. A pretreatment step is frequently used to make the …
which can be converted to biofuels. A pretreatment step is frequently used to make the …
[HTML][HTML] Evolution reveals a glutathione-dependent mechanism of 3-hydroxypropionic acid tolerance
KR Kildegaard, BM Hallström, TH Blicher… - Metabolic …, 2014 - Elsevier
Abstract Biologically produced 3-hydroxypropionic acid (3HP) is a potential source for
sustainable acrylates and can also find direct use as monomer in the production of …
sustainable acrylates and can also find direct use as monomer in the production of …
Pathway optimization and key enzyme evolution of N-acetylneuraminate biosynthesis using an in vivo aptazyme-based biosensor
N-acetylneuraminate (NeuAc) biosynthesis has drawn much attention owing to its wide
applications in many aspects. Previously, we engineered for the first time an artificial NeuAc …
applications in many aspects. Previously, we engineered for the first time an artificial NeuAc …
Genes restoring redox balance in fermentation-deficient E. coli NZN111
The objectives of this study were to improve understanding of the biochemical mechanisms
underlying the growth defects resulting from deletion of pflB and ldhA in E. coli (strain …
underlying the growth defects resulting from deletion of pflB and ldhA in E. coli (strain …