[HTML][HTML] The mechanisms of pharmacokinetic food-drug interactions–A perspective from the UNGAP group

M Koziolek, S Alcaro, P Augustijns, AW Basit… - European Journal of …, 2019 - Elsevier
The simultaneous intake of food and drugs can have a strong impact on drug release,
absorption, distribution, metabolism and/or elimination and consequently, on the efficacy …

[HTML][HTML] The influence of the gut microbiota on the bioavailability of oral drugs

X Zhang, Y Han, W Huang, M Jin, Z Gao - Acta Pharmaceutica Sinica B, 2021 - Elsevier
Due to its safety, convenience, low cost and good compliance, oral administration attracts
lots of attention. However, the efficacy of many oral drugs is limited to their unsatisfactory …

Bile acids and their derivatives as potential modifiers of drug release and pharmacokinetic profiles

N Pavlović, S Goločorbin-Kon, M Ðanić… - Frontiers in …, 2018 - frontiersin.org
Bile acids have received considerable interest in the drug delivery research due to their
peculiar physicochemical properties and biocompatibility. The main advantage of bile acids …

Safety of probiotics: functional fruit beverages and nutraceuticals

I Žuntar, Z Petric, D Bursać Kovačević, P Putnik - Foods, 2020 - mdpi.com
Over the last decade, fruit juice consumption has increased. Their rise in popularity can be
attributed to the belief that they are a quick way to consuming a dietary portion of fruit …

Bile acid synthesis: from nature to the chemical modification and synthesis and their applications as drugs and nutrients

TM Šarenac, M Mikov - Frontiers in Pharmacology, 2018 - frontiersin.org
Bile acids (BAs) are amphiphilic molecules with 24 carbon atoms and consist of a
hydrophobic and a rigid steroid nucleus, to which are attached a hydrophilic hydroxyl group …

Pharmacological applications of bile acids and their derivatives in the treatment of metabolic syndrome

M Ðanić, B Stanimirov, N Pavlović… - Frontiers in …, 2018 - frontiersin.org
Apart from well-known functions of bile acids in digestion and solubilization of lipophilic
nutrients and drugs in the small intestine, the emerging evidence from the past two decades …

[HTML][HTML] Exploring the potential impact of probiotic use on drug metabolism and efficacy

C Purdel, A Ungurianu, I Adam-Dima… - Biomedicine & …, 2023 - Elsevier
Probiotics are frequently consumed as functional food and widely used as dietary
supplements, but are also recommended in treating or preventing various gastrointestinal …

Antidiabetic plants for the treatment of type 2 diabetes mellitus and associated Bacterial infections

MA Tienda-Vázquez, EM Melchor-Martínez… - Processes, 2023 - mdpi.com
Type 2 diabetes mellitus (T2DM) is the metabolic disease with the highest morbidity rates
worldwide. The condition is characterized by hyperglycemia, insulin resistance …

Semisynthetic bile acids: a new therapeutic option for metabolic syndrome

S Lazarević, M Đanić, S Goločorbin-Kon… - Pharmacological …, 2019 - Elsevier
Bile acids are endogenous emulsifiers synthesized from cholesterol having a peculiar
amphiphilic structure. Appreciation of their beneficial effects on human health, recognized …

Beneficial Effects of Ursodeoxycholic Acid on Metabolic Parameters and Oxidative Stress in Patients with Type 2 Diabetes Mellitus: A Randomized Double‐Blind …

B Lakić, R Škrbić, S Uletilović… - Journal of Diabetes …, 2024 - Wiley Online Library
Background. Oxidative stress and inflammation are closely related pathophysiological
processes, both occurring in type 2 diabetes mellitus (T2DM). In addition to the standard …