Secondary metabolites obtained from natural sources are medicinally relevant molecules.
About one-third of all FDA-approved drugs are derived from or based on natural products …

Background: The American trypanosomiasis, Chagas disease, is a parasitic infection
typically spread by triatomine vectors affecting millions of people all over Latin America …

Natural products comprise valuable sources for new antiparasitic drugs. Here we tested the
effects of a novel β–lapachone derivative on Trypanosoma cruzi parasite survival and …

Curcumin (CUR) is the major constituent of the rhizomes of Curcuma longa and has been
widely investigated for its chemotherapeutic properties. The well-known activity of CUR …

Leishmaniasis chemotherapy is a bottleneck in disease treatment. Although available,
chemotherapy is limited, toxic, painful, and does not lead to parasite clearance, with parasite …

In the absence of accessible, effective vaccines, the fight against parasitic disease relies
mostly on chemotherapy. Nevertheless, the considerable side effects, high costs and …

The present study was aimed to isolate active constituents from Blumea axillaris (Lam.) DC
(Asteraceae) against phytopathogenic fungi. Bioactivity guided fractionation of the …

O benznidazol (BDZ) é um fármaco utilizado no tratamento da doença de Chagas (DC) há
mais de 40 anos. O dissulfiram (DSF) foi inicialmente registrado como adjuvante no …

In the present study, a series of new esters of secochiliolide acid (SA), a diterpene isolated
from Nardophyllum bryoides, were synthesized in good yield. All compounds were …

The present study was aimed to isolate active constituents from Blumea axillaris (Lam.) DC
(Asteraceae) against phytopathogenic fungi. Bioactivity guided fractionation of the …