Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production

A Michelucci, T Cordes, J Ghelfi… - Proceedings of the …, 2013 - National Acad Sciences
Immunoresponsive gene 1 (Irg1) is highly expressed in mammalian macrophages during
inflammation, but its biological function has not yet been elucidated. Here, we identify Irg1 as …

Photodynamic therapy: a review of applications in neurooncology and neuropathology

AB Uzdensky, E Berezhnaya… - … of biomedical optics, 2015 - spiedigitallibrary.org
Photodynamic therapy (PDT) effect is a promising adjuvant modality for diagnosis and
treatment of brain cancer. It is of importance that the bright fluorescence of most …

Protection of the crayfish mechanoreceptor neuron and glial cells from photooxidative injury by modulators of diverse signal transduction pathways

A Uzdensky, E Berezhnaya, A Khaitin, V Kovaleva… - Molecular …, 2015 - Springer
Oxidative stress is the reason of diverse neuropathological processes. Photodynamic
therapy (PDT), an effective inducer of oxidative stress, is used for cancer treatment, including …

Ca2+ mediates axotomy-induced necrosis and apoptosis of satellite glial cells remote from the transection site in the isolated crayfish mechanoreceptor

A Khaitin, M Rudkovskii, A Uzdensky - Molecular and Cellular …, 2018 - Elsevier
Severe nerve injury such as axotomy induces neuron degeneration and death of
surrounding glial cells. Using a crayfish stretch receptor that consists of a single …

[HTML][HTML] Са2+-and NF-κB-dependent generation of NO in the photosensitized neurons and satellite glial cells

SV Rodkin, VD Kovaleva, EV Berezhnaya… - … of Photochemistry and …, 2019 - Elsevier
Photodynamic therapy (PDT) is used for killing of malignant cells in tumors including brain
cancer. It can also damage normal neurons and glial cells. Nitric oxide (NO) is known to …

[HTML][HTML] Ameliorating of memory impairment and apoptosis in amyloid β-injected rats via inhibition of nitric oxide synthase: possible participation of autophagy

M Shariatpanahi, F Khodagholi, G Ashabi… - Iranian journal of …, 2015 - ncbi.nlm.nih.gov
It has been proposed that appearance of amyloid beta (Aβ) in hippocampus is one of the
characteristic features of Alzheimer's disease (AD). The role of Nitric oxide (NO) in …

Photodynamic therapy-induced nitric oxide production in neuronal and glial cells

VD Kovaleva, AB Uzdensky - Journal of Biomedical Optics, 2016 - spiedigitallibrary.org
Nitric oxide (NO) has been recently demonstrated to enhance apoptosis of glial cells
induced by photodynamic therapy (PDT), but to protect glial cells from PDT-induced necrosis …

Epigenetic regulation of death of crayfish glial cells but not neurons induced by photodynamic impact

SA Sharifulina, MA Komandirov, AB Uzdensky - Brain research bulletin, 2014 - Elsevier
Epigenetic processes are involved in regulation of cell functions and survival, but their role
in responses of neurons and glial cells to oxidative injury is insufficiently explored. Here, we …

Nitrosylhemoglobin in photodynamically stressed human tumors growing in nude mice

M Jakubowska, D Michalczyk-Wetula, J Pyka, A Susz… - Nitric Oxide, 2013 - Elsevier
The role of nitric oxide in human tumor biology and therapy has been the subject of
extensive studies. However, there is only limited knowledge about the mechanisms of NO …

Responses of crayfish neurons and glial cells to photodynamic impact: intracellular signaling, ultrastructural changes, and neuroglial interactions

AB Uzdensky, MV Rudkovskii, GM Fedorenko… - … ) Supplement Series A …, 2014 - Springer
Photodynamic therapy (PDT), an inducer of oxidative stress, is used for treatment of cancer,
including brain tumors. To study the mechanisms of photodynamic injury of neurons and …