Colorectal cancer (CRC) is a predominant malignancy worldwide, being the fourth most
common cause of mortality and morbidity. The CRC incidence in adolescents, young adults …

Although chemotherapy, targeted therapy and endocrine therapy decrease rate of disease
recurrence in most breast cancer patients, many patients exhibit acquired resistance …

Among cancers, leukemia is a multistep progression that involves genetic modifications of
normal hematopoietic progenitor cells to cancerous cells. In recent times, leukemia cases …

Pancreatic cancer is an extremely malignant digestive tract tumor. With the increase of
chemotherapeutic resistance of pancreatic cancer, clinical treatment is in a dilemma. Hence …

Abstract N6-methyladenosine (m6A) demethylase fat mass and obesity-associated gene
(FTO), previously recognized to be related with obesity and diabetes, was gradually …

Objectives Partial or total resistance to preoperative chemoradiotherapy occurs in more than
half of locally advanced rectal cancer patients. Several novel or repurposed drugs have …

Globally, there are over half a million new patients with head and neck squamous cell
carcinomas (HNSCC) every year. The current therapeutic approaches to HNSCC are …

DNA double-strand break (DSB) is considered the most deleterious type of DNA damage,
which is generated by ionizing radiation (IR) and a subset of anticancer drugs. DNA …

Major advances have been made in precision medicine of breast cancer patients with a
series of molecular targeted therapies now in clinical use or in late clinical development …

Background Targeting AKT suppresses tumor growth through inducing apoptosis, however,
during which whether other forms of cell death occurring is poorly understood. Methods The …