Bipolar disorders are chronic and recurrent disorders that affect> 1% of the global
population. Bipolar disorders are leading causes of disability in young people as they can …

The average age of fathers at first pregnancy has risen significantly over the last decade
owing to various variables, including a longer life expectancy, more access to contraception …

Over the last decade, there has been a significant increase in average paternal age when
the first child is conceived, either due to increased life expectancy, widespread use of …

Objective Advanced parental age has raised additional concern as a risk factor of autism.
We conducted a meta‐analysis of observational studies investigating the association …

Importance Advancing paternal age is associated with increased genetic mutations during
spermatogenesis, which research suggests may cause psychiatric morbidity in the offspring …

BACKGROUND Maternal factors, including increasing childbearing age and various life-
style factors, are associated with poorer short-and long-term outcomes for children, whereas …

Context Persons with schizophrenia are thought to be at increased risk of committing violent
crime 4 to 6 times the level of general population individuals without this disorder. However …

Recent evidence demonstrates a role for paternal aging on offspring disease susceptibility. It
is well established that various neuropsychiatric disorders (schizophrenia, autism, etc.) …

DNA damage in the male germ line has been linked with a variety of adverse clinical
outcomes including impaired fertility, an increased incidence of miscarriage and an …

Context It is unknown how genetic variants conferring liability to psychiatric disorders survive
in the population despite strong negative selection. However, this is key to understanding …