Anecdotal evidence that cannabis preparations have medical benefits together with the
discovery of the psychotropic plant cannabinoid Δ9-tetrahydrocannabinol (THC) initiated …

Cannabinoid receptors, endocannabinoids and the enzymes responsible for their
biosynthesis and degradation constitute the endocannabinoid system. In recent decades …

Macrophages are important players in the fight against viral, bacterial, fungal and parasitic
infections. From a resting state they may undertake two activation pathways, the classical …

The endocannabinoid system (ECS) is composed of two G protein-coupled receptors
(GPCRs), the cannabinoid CB1 and CB2 receptors, and the two main endogenous lipid …

Parkinson's disease (PD) is a chronic and progressive disorder characterized
neuropathologically by loss of dopamine neurons in the substantia nigra, intracellular …

Parkinson's disease (PD) is a neurodegenerative disease characterized by a progressive
loss of dopaminergic neurons from the nigrostriatal pathway, formation of Lewy bodies, and …

Microglia, the resident immune cells of the central nervous system, mediate brain
homeostasis by controlling neuronal proliferation/differentiation and synaptic activity. In …

Abstract Endocannabinoid (eCB), 2-arachidonoyl-glycerol (2-AG), the most abundant eCB in
the brain, regulates diverse neural functions. Here we linked multiple homozygous loss-of …

Recent years have yielded significant advances in our understanding of microglia, the
immune cells of the central nervous system (CNS). Microglia are key players in CNS …

Endocannabinoids are endogenous lipid signaling mediators that participate in a variety of
physiological and pathological processes. 2-Arachidonoylglycerol (2-AG) is the most …