With the advent of X-ray free-electron lasers (XFELs), new, high-throughput serial
crystallography techniques for macromolecular structure determination have emerged …

The design of proteins that bind to a specific site on the surface of a target protein using no
information other than the three-dimensional structure of the target remains a challenge …

Data curation practices of the Crystallography Open Database (COD) are described with
additional focus being placed on the formal validation using the Crystallographic Information …

The field of Structural Genomics arose over the last 3 decades to address a large and
rapidly growing divergence between microbial genomic, functional, and structural data …

Sharing data has a crucial role in the advancement of biological science. The use of different
types of data within and between scientific fields complicates establishing a single standard …

Drugs targeting multiple stages of the Plasmodium vivax life cycle are needed to reduce the
health and economic burdens caused by malaria worldwide. N-myristoyltransferase (NMT) …

Every day, hundreds of millions of people worldwide take nonsteroidal anti-inflammatory
drugs (NSAIDs), often in conjunction with multiple other medications. In the bloodstream …

There is an unmet medical need for effective treatments against Mycobacterium abscessus
pulmonary infections, to which cystic fibrosis (CF) patients are particularly vulnerable …

Each year, approximately 50,000 children under 5 die as a result of diarrhea caused by
Cryptosporidium parvum, a protozoan parasite. There are currently no effective drugs or …

Calcineurin is an essential virulence factor that is conserved across human fungal
pathogens, including Cryptococcus neoformans, Aspergillus fumigatus, and Candida …