To enhance glucose uptake into muscle and fat cells, insulin stimulates the translocation of
GLUT4 glucose transporters from intracellular membranes to the cell surface. This response …

VPS10P-domain receptors, such as SORLA and sortilin, constitute a recently identified class
of type-1 receptors that are expressed in neurons. Family members are multifunctional …

BACKGROUND: Whether triglyceride-mediated pathways are causally relevant to coronary
heart disease is uncertain. We studied a genetic variant that regulates triglyceride …

Recent genome-wide association studies (GWAS) have revealed strong association of
hypercholesterolemia and myocardial infarction with SNPs on human chromosome 1p13. 3 …

OBJECTIVE The metabolic syndrome (MetS) is defined as concomitant disorders of lipid and
glucose metabolism, central obesity, and high blood pressure, with an increased risk of type …

Sortilin is a post-Golgi trafficking receptor homologous to the yeast vacuolar protein sorting
receptor 10 (VPS10). The VPS10 motif on sortilin is a 10-bladed β-propeller structure …

Genome-wide association studies (GWAS) have identified a genetic variant at a locus on
chromosome 1p13 that is associated with reduced risk of myocardial infarction, reduced …

The family of mammalian type-I transmembrane receptors containing a Vps10p domain
contains five members, Sortilin, SorCS1, SorCS2, SorCS3, and SorLA. The common …

Optical biosensor technology continues to be the method of choice for label‐free, real‐time
interaction analysis. But when it comes to improving the quality of the biosensor literature …

During their metabolism, all lipoproteins undergo endocytosis, either to be degraded
intracellularly, for example in hepatocytes or macrophages, or to be re-secreted, for example …