The expression of MHC class I molecules is crucial for the initiation and regulation of
adaptive immune responses against pathogens. NOD-, LRR-and CARD-containing 5 …

The presentation of peptides to T cells by MHC class II molecules is of critical importance in
specific recognition by the immune system. Expression of class II molecules is exquisitely …

The functional diversity of natural killer (NK) cell repertoires stems from differentiation,
homeostatic, receptor–ligand interactions and adaptive-like responses to viral infections. In …

Recent outbreaks of Ebola virus (EBOV) and severe acute respiratory syndrome coronavirus
2 (SARS-CoV-2) have exposed our limited therapeutic options for such diseases and our …

The transactivation domain of the cAMP response element-binding protein (CREB) consists
of two major domains. The glutamine-rich Q2 domain, which interacts with the general …

The bare lymphocyte syndrome (BLS) is a hereditary immunodeficiency resulting from the
absence of major istocompatibility complex class II (MHCII) expression. Considering the …

The CCAAT box promoter element and NF-Y, the transcription factor (TF) that binds to it,
were among the first cis-elements and trans-acting factors identified; their interplay is …

▪ Abstract The newly discovered CATERPILLER (CLR) gene family encodes proteins with a
variable but limited number of N-terminal domains, followed by a nucleotide-binding domain …

The newly described CATERPILLER family (also known as NOD-LRR or NACHT-LRR) is
comprised of proteins with a nucleotide-binding domain and a leucine-rich region. This …

Mycobacterium tuberculosis (MTB) persists inside macrophages despite vigorous immune
responses. MTB and MTB 19-kDa lipoprotein inhibit class II MHC (MHC-II) expression and …