Abstract Major Depressive Disorder (MDD) is one of the most common and debilitating
mental disorders; however, its etiology remains unclear. This paper aims to summarize the …

The hippocampus provided the gateway into much of what we have learned about stress
and brain structural and functional plasticity, and this initial focus has expanded to other …

This paper is the first review into the automatic analysis of speech for use as an objective
predictor of depression and suicidality. Both conditions are major public health concerns; …

Stress is a state of the mind, involving both brain and body as well as their interactions; it
differs among individuals and reflects not only major life events but also the conflicts and …

The brain is the central organ for adaptation to experiences, including stressors, which are
capable of changing brain architecture as well as altering systemic function through …

As the central organ of stress and adaptation to stressors, the brain plays a pivotal role in
behavioral and physiological responses that may lead to successful adaptation or to …

The allostatic load model expands the stress-disease literature by proposing a temporal
cascade of multi-systemic physiological dysregulations that contribute to disease …

A scientific consensus is emerging that the origins of adult disease are often found among
developmental and biological disruptions occurring during the early years of life. These …

The brain is the key organ of stress processes. It determines what individuals will experience
as stressful, it orchestrates how individuals will cope with stressful experiences, and it …

Emotionally significant experiences tend to be well remembered, and the amygdala has a
pivotal role in this process. But the efficient encoding of emotional memories can become …