High affinity human antibodies to PCSK9

MW Sleeman, JH Martin, TT Huang… - US Patent …, 2011 - Google Patents
An human antibody or antigen-binding fragment of a human antibody that specifically binds
and inhibits human proprotein convertase subtilisin/kexin type 9 (hPCSK9) characterized by …

Antigen binding proteins to proprotein convertase subtilisin kexin type 9 (PCSK9)

SM Jackson, NPC Walker, DE Piper, W Shen… - US Patent …, 2014 - Google Patents
First worldwide family litigation filed litigation https://patents. darts-ip. com/? family=
39951467&utm_source= google_patent&utm_medium= platform_link&utm_campaign …

Methods of using antigen binding proteins to proprotein convertase subtilisin kexin type 9 (PCSK9)

SM Jackson, NPC Walker, DE Piper, B Shan… - US Patent …, 2015 - Google Patents
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
39951467&utm_source= google_patent&utm_medium= platform_link&utm_campaign …

Antigen binding proteins to proprotein convertase subtilistin kexin type 9 (pcsk9)

SM Jackson, NPC Walker, DE Piper, B Shan, W Shen… - 2017 - Google Patents
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
39951467&utm_source= google_patent&utm_medium= platform_link&utm_campaign …

High affinity human antibodies to PCSK9

MW Sleeman, JH Martin, TT Huang… - US Patent …, 2013 - Google Patents
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
41668268&utm_source= google_patent&utm_medium= platform_link&utm_campaign …

Antigen binding proteins to proprotein convertase subtilisin kexin type 9 (PCSK9)

SM Jackson, B Shan, W Shen, CT King - US Patent 8,168,762, 2012 - Google Patents
Antigen binding proteins that interact with Proprotein Convertase Subtilisin Kexin Type 9
(PCSK9) are described. Methods of treating hypercholesterolemia and other disorders by …

Methods for treating hypercholesterolemia using antibodies to PCSK9

MW Sleeman, JH Martin, TT Huang… - US Patent …, 2013 - Google Patents
US8357371B2 - Methods for treating hypercholesterolemia using antibodies to PCSK9 -
Google Patents US8357371B2 - Methods for treating hypercholesterolemia using …

Anti-PCSK9 antibodies and use thereof

AL Feldhaus, LF Garcia-Martinez, BH Dutzar… - US Patent …, 2016 - Google Patents
2013-05-07 Assigned to ALDER BIOPHARMACEUTICALS, INC. reassignment ALDER
BIOPHARMACEUTICALS, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE …

Anti-PCSK9 antibodies with pH-dependent binding characteristics

GD Yancopoulos, NJ Papadopoulos… - US Patent …, 2017 - Google Patents
The present invention provides antibodies and antigen-binding fragments thereof that
specifically bind proprotein convertase subtilisin/kexin-9 (PCSK9) with greater affinity at …

Methods for reducing remnant cholesterol and other lipoprotein fractions by administering an inhibitor of proprotein convertase subtilisin kexin-9 (PCSK9)

G Swergold, WJ Sasiela, RC Pordy - US Patent 10,111,953, 2018 - Google Patents
The present invention provides methods for reducing various lipoprotein fractions in the
serum of patients. The methods of the invention include reducing serum remnant …