FOXO proteins are transcription factors that are involved in numerous physiological
processes and in various pathological conditions, including cardiovascular disease, cancer …

Heart disease is a major cause of death worldwide with increasing prevalence, which urges
the development of new therapeutic strategies. Over the last few decades, numerous small …

Left ventricular hypertrophy is a leading risk factor for cardiovascular morbidity and mortality.
Although reverse ventricular remodelling was long thought to be irreversible, evidence from …

Background—Mitochondrial autophagy is an important mediator of mitochondrial quality
control in cardiomyocytes. The occurrence of mitochondrial autophagy and its significance …

Oxidative stress has long been implicated in cardiovascular disease, but more recently, the
role of reactive oxygen species (ROS) in normal physiological signaling has been …

Members of the class O of forkhead box transcription factors (FOXO) have important roles in
metabolism, cellular proliferation, stress resistance, and apoptosis. The activity of FOXOs is …

Damaged mitochondria pose a lethal threat to cells that necessitates their prompt removal.
The currently recognized mechanism for disposal of mitochondria is autophagy, where …

Fork head box O (FOXO) transcription factor is a key player in an evolutionarily conserved
pathway. The mammalian FOXO family consists of FOXO1, 3, 4 and 6, are highly similar in …

Despite recent scientific and technological advances, cardiovascular disease remains the
leading cause of morbidity and mortality worldwide. Autophagy, an evolutionarily ancient …

Reperfusion injury is an inherent response to the restoration of blood flow after ischemia. It is
a complex process involving numerous mechanisms occurring in the intracellular and …