Targeted gene mutations have established distinct, yet overlapping, developmental roles for
receptors of the insulin/IGF family. IGF-I receptor mediates IGF-I and IGF-II action on prenatal …

The interaction of insulin with its cell surface receptor is the first step in insulin action and the
first identified target of insulin resistance. The insulin resistance in several syndromic forms …

▪ Abstract To examine the role of the insulin receptor in fuel homeostasis, we and others
have carried out genetic ablation studies in mice. Mice lacking insulin receptors are born …

Insulin resistance (IR) is insulin failure in normal plasma levels to adequately stimulate
glucose uptake by the peripheral tissues. IR is becoming more common in children and …

Nandi, Anindita, Yukari Kitamura, C. Ronald Kahn, and Domenico Accili. Mouse Models of
Insulin Resistance. Physiol Rev 84: 623–647, 2004; 10.1152/physrev. 00032.2003.—Insulin …

The insulin receptor is a ligand-activated tyrosine kinase. Mutations in the corresponding
gene cause the rare inherited insulin-resistant disorders leprechaunism and Rabson …

We have investigated the metabolic actions of recombinant human IGF-1 in mice genetically
deficient of insulin receptors (IR-/-). After intraperitoneal administration, IGF-1 caused a …

Hypertrophic cardiomyopathy (HCM) in neonates is a rare and heterogeneous disorder
which is characterized by hypertrophy of heart with histological and functional disruption of …

A. African Efe Pygmies B. Leprechaunism and other genetic disorders associated with
severe insulin resistance C. Deletions of the distal arm of chromosome 15 D. Rare examples …

Observations in targeted mouse mutants and patients with genetic abnormalities grant
insight into the various and distinct roles of insulin-like growth factor receptors (IGF-Rs) and …