Mechanobiology in oncology: basic concepts and clinical prospects

MB Chen, Y Javanmardi, S Shahreza… - Frontiers in Cell and …, 2023 - frontiersin.org
The interplay between genetic transformations, biochemical communications, and physical
interactions is crucial in cancer progression. Metastasis, a leading cause of cancer-related …

2.5 D traction force microscopy: imaging three-dimensional cell forces at interfaces and biological applications

H Delanoë-Ayari, T Hiraiwa, P Marcq, JP Rieu… - The international journal …, 2023 - Elsevier
The forces that cells, tissues, and organisms exert on the surface of a soft substrate can be
measured using Traction Force Microscopy (TFM), an important and well-established …

Endothelium and subendothelial matrix mechanics modulate cancer cell transendothelial migration

Y Javanmardi, A Agrawal, A Malandrino… - Advanced …, 2023 - Wiley Online Library
Cancer cell extravasation, a key step in the metastatic cascade, involves cancer cell arrest
on the endothelium, transendothelial migration (TEM), followed by the invasion into the …

Evaluating the impact of a biomimetic mechanical environment on cancer invasion and matrix remodeling

A Micalet, J Pape, D Bakkalci… - Advanced …, 2023 - Wiley Online Library
The stiffness of tumors and their host tissues is much higher than most hydrogels, which are
conventionally used to study in vitro cancer progression. The tumoroid assay is an …

Optimal mechanical interactions direct multicellular network formation on elastic substrates

PS Noerr, JE Zamora Alvarado… - Proceedings of the …, 2023 - National Acad Sciences
Cells self-organize into functional, ordered structures during tissue morphogenesis, a
process that is evocative of colloidal self-assembly into engineered soft materials …

Hippocampus of the APPNL–G–F mouse model of Alzheimer's disease exhibits region-specific tissue softening concomitant with elevated astrogliosis

CM Hall, S Lasli, B Serwinski, B Djordjevic… - Frontiers in Aging …, 2023 - frontiersin.org
Widespread neurodegeneration, enlargement of cerebral ventricles, and atrophy of cortical
and hippocampal brain structures are classic hallmarks of Alzheimer's disease (AD) …

Analysis of the compressible, isotropic, neo-Hookean hyperelastic model

A Kossa, MT Valentine, RM McMeeking - Meccanica, 2023 - Springer
The most widely-used representation of the compressible, isotropic, neo-Hookean
hyperelastic model is considered in this paper. The version under investigation is that which …

Nanocomposite hydrogels with temperature response for capacitive energy storage

J Garcia-Torres, S Colombi, I Mahamed… - ACS Applied Energy …, 2023 - ACS Publications
Functional hydrogels are three-dimensional polymeric networks with potential applicability
in the field of wearable electronics. However, hydrogels are often used to develop devices …

Experimental and data analysis workflow for soft matter nanoindentation

G Ciccone, MA Gonzalez Oliva… - Journal of …, 2022 - research-collection.ethz.ch
Nanoindentation refers to a class of experimental techniques where a micrometric force
probe is used to quantify the local mechanical properties of soft biomaterials and cells. This …

[HTML][HTML] Stromal cells regulate mechanics of tumour spheroid

A Agrawal, S Lasli, Y Javanmardi, D Coursier… - Materials Today Bio, 2023 - Elsevier
The remarkable contractility and force generation ability exhibited by cancer cells empower
them to overcome the resistance and steric hindrance presented by a three-dimensional …