Currently, more than 170 modifications have been identified on RNA. Among these RNA
modifications, various methylations account for two-thirds of total cases and exist on almost …

Although cancer was originally considered a disease driven only by genetic mutations, it has
now been proven that it is also an epigenetic disease driven by DNA hypermethylation …

Epitranscriptomic RNA modifications can regulate fundamental biological processes, but we
lack approaches to map modification sites and probe writer enzymes. Here we present a …

AlkB homologs (ALKBH) are a family of specific demethylases that depend on Fe 2+ and α-
ketoglutarate to catalyze demethylation on different substrates, including ssDNA, dsDNA …

The human mitochondrial genome (mtDNA) regulates its transcription products in
specialised and distinct ways as compared to nuclear transcription. Thanks to its mtDNA …

ABSTRACT tiRNAs are small non-coding RNAs produced when tRNA is cleaved under
stress. tRNA methylation modifications has emerged in recent years as important regulators …

Lung cancer has surpassed breast cancer as the leading cause of cancer death in females
in developed countries and the leading cause of cancer death in males. Despite extensive …

Replication of the mitochondrial genome and expression of the genes it encodes both
depend on a sufficient supply of nucleotides to mitochondria. Accordingly, dysregulated …

Methylation of carbon‐5 of cytosines (m5C) is a post‐transcriptional nucleotide modification
of RNA found in all kingdoms of life. While individual m5C‐methyltransferases have been …

Cytochrome P450 (CYP) 1B1 belongs to the superfamily of heme-containing
monooxygenases. Unlike other CYP enzymes, which are highly expressed in the liver …