Recommendations for measuring HIV reservoir size in cure-directed clinical trials
M Abdel-Mohsen, D Richman, RF Siliciano… - Nature medicine, 2020 - nature.com
Therapeutic strategies are being clinically tested either to eradicate latent HIV reservoirs or
to achieve virologic control in the absence of antiretroviral therapy. Attaining this goal will …
to achieve virologic control in the absence of antiretroviral therapy. Attaining this goal will …
HIV persists throughout deep tissues with repopulation from multiple anatomical sources
BACKGROUND Understanding HIV dynamics across the human body is important for cure
efforts. This goal has been hampered by technical difficulties and the challenge of obtaining …
efforts. This goal has been hampered by technical difficulties and the challenge of obtaining …
CD4+ T‐cell depletion in HIV infection: mechanisms of immunological failure
The hallmark of acquired immunodeficiency syndrome (AIDS) pathogenesis is a progressive
depletion of CD 4+ T‐cell populations in close association with progressive impairment of …
depletion of CD 4+ T‐cell populations in close association with progressive impairment of …
Past, present and future: 30 years of HIV research
F Barré-Sinoussi, AL Ross, JF Delfraissy - Nature Reviews Microbiology, 2013 - nature.com
This year marks the thirtieth anniversary of the publication of the study that first reported the
isolation of HIV-1. In this Timeline article, we provide a historical perspective of some of the …
isolation of HIV-1. In this Timeline article, we provide a historical perspective of some of the …
Follicular helper T cells serve as the major CD4 T cell compartment for HIV-1 infection, replication, and production
M Perreau, AL Savoye, E De Crignis… - Journal of Experimental …, 2013 - rupress.org
In the present study, we have investigated the distribution of HIV-specific and HIV-infected
CD4 T cells within different populations of memory CD4 T cells isolated from lymph nodes of …
CD4 T cells within different populations of memory CD4 T cells isolated from lymph nodes of …
HIV‐associated chronic immune activation
M Paiardini, M Müller‐Trutwin - Immunological reviews, 2013 - Wiley Online Library
Systemic chronic immune activation is considered today as the driving force of CD 4+ T‐cell
depletion and acquired immunodeficiency syndrome (AIDS). A residual chronic immune …
depletion and acquired immunodeficiency syndrome (AIDS). A residual chronic immune …
Tissue reservoirs of HIV
JK Wong, SA Yukl - Current Opinion in HIV and AIDS, 2016 - journals.lww.com
The retention of infected cells in a wide variety of tissues, often with distinct viral and cellular
characteristics, underscores the importance of studying tissue reservoirs in the development …
characteristics, underscores the importance of studying tissue reservoirs in the development …
Dissecting how CD4 T cells are lost during HIV infection
Although the replicative life cycle of HIV within CD4 T cells is understood in molecular detail,
less is known about how this human retrovirus promotes the loss of CD4 T lymphocytes. It is …
less is known about how this human retrovirus promotes the loss of CD4 T lymphocytes. It is …
Multiple organ infection and the pathogenesis of SARS
J Gu, E Gong, B Zhang, J Zheng, Z Gao… - The Journal of …, 2005 - rupress.org
After> 8,000 infections and> 700 deaths worldwide, the pathogenesis of the new infectious
disease, severe acute respiratory syndrome (SARS), remains poorly understood. We …
disease, severe acute respiratory syndrome (SARS), remains poorly understood. We …