Recent advances in the determination of elemental impurities in pharmaceuticals–Status, challenges and moving frontiers

V Balaram - Trac trends in Analytical chemistry, 2016 - Elsevier
Elemental impurities have been regulated in pharmaceutical products for many decades.
Metal impurities such as As, Cd, Cu, Pb, Hg, V and Pt in pharmaceuticals and drugs are …

Review on grazing incidence X-ray spectrometry and reflectometry

KN Stoev, K Sakurai - Spectrochimica Acta Part B: Atomic Spectroscopy, 1999 - Elsevier
Grazing incidence X-ray techniques are now widely used for surface and thin film analysis.
The present article overviews the recent advancement since 1993 of the grazing incidence X …

Analytical approach of elemental impurities in pharmaceutical products: a worldwide review

ACM Aleluia, M de Souza Nascimento… - … Acta Part B: Atomic …, 2023 - Elsevier
Elemental impurities may occur in pharmaceutical products under different conditions.
Impurity composition includes many types of species: metals and non-metals, which can be …

The use of total reflectance X-ray fluorescence (TXRF) for the determination of metals in the pharmaceutical industry

FJ Antosz, Y Xiang, AR Diaz, AJ Jensen - Journal of pharmaceutical and …, 2012 - Elsevier
The control of residual metals in active pharmaceutical ingredients (API's) and intermediates
is critical because of their potential toxic effects. A variety of technologies are available to …

The assessment of a method for measurements and lead quantification in air particulate matter using total reflection X-ray fluorescence spectrometers

L Borgese, F Bilo, A Zacco, S Federici… - … Acta Part B: Atomic …, 2020 - Elsevier
This paper presents the assessment of a direct method to measure and analyse Pb in air
particulate matter (PM) collected on polytetrafluoroethylene (PTFE) filtering membranes …

Applicability of total reflection X-ray fluorescence (TXRF) as a screening platform for pharmaceutical inorganic impurity analysis

BJ Shaw, DJ Semin, ME Rider, MR Beebe - Journal of pharmaceutical and …, 2012 - Elsevier
Palladium (Pd) is extensively used in pharmaceutical small molecule drug substance
processes, however it must be removed prior to release of the active pharmaceutical …

Quality control of commercial tea by x‐ray fluorescence

MJ Salvador, GN Lopes… - X‐Ray Spectrometry …, 2002 - Wiley Online Library
Based on the energy‐dispersive x‐ray fluorescence (EDXRF) technique, the concentrations
of elements (22≤ Z≤ 30) were assessed in five kinds of commercial tea from six …

Use of total reflection X-ray fluorescence (TXRF) for the evaluation of heavy metal poisoning due to the improper use of a traditional ayurvedic drug

L Borgese, A Zacco, E Bontempi, M Pellegatta… - … of pharmaceutical and …, 2010 - Elsevier
An Indian patient referred to Clinica del Lavoro 'L. Devoto'of Milano showed clinical signs of
heavy metal poisoning, possibly related to a sustained 6-month use of approx. 3g/day of a …

A comprehensive review on assessment and key control strategies for impurities in drug development with a special emphasis on post-marketing surveillance

N Tapkir, F Soni, AK Sahu, T Jadav, RK Tekade… - Journal of …, 2021 - Springer
The presence of impurities is the primary cause of safety related drug product recall. Clinical
data generated during the drug discovery process may not be able to conclude the long …

Inorganic analysis of falsified medical products using X-ray fluorescence spectroscopy and chemometrics

H Rebiere, A Kermaïdic, C Ghyselinck, C Brenier - Talanta, 2019 - Elsevier
Falsified medical products are increasingly prevalent on markets, threatening the health of
patients. This study describes the benefits of Energy Dispersive X-Ray Fluorescence (ED …