The evolving story of incretins (GIP and GLP‐1) in metabolic and cardiovascular disease: a pathophysiological update

MA Nauck, DR Quast, J Wefers… - Diabetes, Obesity and …, 2021 - Wiley Online Library
The incretin hormones glucose‐dependent insulinotropic polypeptide (GIP) and glucagon‐
like peptide‐1 (GLP‐1) have their main physiological role in augmenting insulin secretion …

[HTML][HTML] Glucagon-like peptide 1 (GLP-1)

TD Müller, B Finan, SR Bloom, D D'Alessio… - Molecular …, 2019 - Elsevier
Background The glucagon-like peptide-1 (GLP-1) is a multifaceted hormone with broad
pharmacological potential. Among the numerous metabolic effects of GLP-1 are the glucose …

Incretin hormones: Their role in health and disease

MA Nauck, JJ Meier - Diabetes, Obesity and Metabolism, 2018 - Wiley Online Library
Incretin hormones are gut peptides that are secreted after nutrient intake and stimulate
insulin secretion together with hyperglycaemia. GIP (glucose‐dependent insulinotropic …

Obesity, polycystic ovary syndrome, and infertility: a new avenue for GLP-1 receptor agonists

H Cena, L Chiovato, RE Nappi - The Journal of Clinical …, 2020 - academic.oup.com
Context Obesity is responsible for an increased risk of sub-fecundity and infertility. Obese
women show poorer reproductive outcomes regardless of the mode of conception, and …

Glucagon-like peptide 1 in health and disease

A Andersen, A Lund, FK Knop, T Vilsbøll - Nature Reviews …, 2018 - nature.com
In healthy individuals, the incretin hormone glucagon-like peptide 1 (GLP1) potentiates
insulin release and suppresses glucagon secretion in response to the ingestion of nutrients …

New frontiers in obesity treatment: GLP-1 and nascent nutrient-stimulated hormone-based therapeutics

AM Jastreboff, RF Kushner - Annual review of medicine, 2023 - annualreviews.org
Nearly half of Americans are projected to have obesity by 2030, underscoring the pressing
need for effective treatments. Glucagon-like peptide 1 receptor agonists (GLP-1 RAs) …

Short-chain fatty acid receptors and gut microbiota as therapeutic targets in metabolic, immune, and neurological diseases

T Ikeda, A Nishida, M Yamano, I Kimura - Pharmacology & therapeutics, 2022 - Elsevier
Dysbiosis is associated with various diseases. The composition and diversity of gut
microbiota affect host physiology through the production of bioactive metabolites. Short …

Ghrelin, CCK, GLP-1, and PYY (3–36): secretory controls and physiological roles in eating and glycemia in health, obesity, and after RYGB

RE Steinert, C Feinle-Bisset, L Asarian… - Physiological …, 2017 - journals.physiology.org
The efficacy of Roux-en-Y gastric-bypass (RYGB) and other bariatric surgeries in the
management of obesity and type 2 diabetes mellitus and novel developments in …

Incretin drugs in diabetic kidney disease: biological mechanisms and clinical evidence

RZ Alicic, EJ Cox, JJ Neumiller, KR Tuttle - Nature Reviews Nephrology, 2021 - nature.com
As the prevalence of diabetes continues to climb, the number of individuals living with
diabetic complications will reach an unprecedented magnitude. The emergence of new …

The arcuate nucleus mediates GLP-1 receptor agonist liraglutide-dependent weight loss

A Secher, J Jelsing, AF Baquero… - The Journal of …, 2014 - Am Soc Clin Investig
Liraglutide is a glucagon-like peptide-1 (GLP-1) analog marketed for the treatment of type 2
diabetes. Besides lowering blood glucose, liraglutide also reduces body weight. It is not fully …