Results The literature search was performed from November 2012 to February 2013 and
updated in August 2014. From 2013 retrieved studies, 405 studies were included. Threshold …

Renal hyperfiltration, defined as an increased glomerular filtration rate above normal values,
is associated with early phases of kidney disease in the setting of various conditions such as …

Background—The primary objective of this mechanistic open-label, stratified clinical trial
was to determine the effect of 8 weeks' sodium glucose cotransporter 2 inhibition with …

Plasma uric acid (PUA) is associated with metabolic, cardiovascular, and renal
abnormalities in patients with type 2 diabetes but is less well understood in type 1 diabetes …

Background: The cardiorenal effects of sodium-glucose cotransporter 2 inhibition
(empagliflozin 25 mg QD) combined with angiotensin-converting enzyme inhibition (ramipril …

Glomerular hypertension and hyperfiltration in early diabetes are associated with
development and progression of diabetic kidney disease. The tubular hypothesis of diabetic …

More than two decades ago, hyperfiltration (HF) in diabetes was postulated to be a
maladaptive response observed early in the course of diabetic kidney disease (DKD), which …

Background Children with type 1 diabetes (T1D) are at higher risk of early adult-onset
cardiovascular disease. We assessed cardiovascular structure and function in adolescents …

Adolescents with Type 1 diabetes mellitus (T1DM) are at risk for hyperfiltration and elevated
urinary albumin-to-creatinine ratio (ACR), which are early indicators of diabetic nephropathy …

Hyperfiltration is an important underlying cause of glomerular dysfunction associated with
several systemic and intrinsic glomerular conditions leading to chronic kidney disease …